Utility of Vasopressin Rescue Therapy in Neonates with Persistent Pulmonary Hypertension of the Newborn

Abstract

Background: Persistent pulmonary hypertension of newborn (PPHN) affects 1.9 per 1000 live births and has a varied mortality ranging between 4-33%. Although inhaled nitric oxide (iNO) has reduced the need for Extracorporeal membrane oxygenation (ECMO) in this population, refractory cases persist. Vasopressin is gaining favor as a treatment modality in neonates despite limited data and concerns for hyponatremia and decreased intestinal perfusion. Objective: To describe the effect of vasopressin on oxygenation and systemic blood …