Neuro Pharmacological Effect of Cyclohexane 1, 2, 3, 4, 5, 6-Hexol and (2Z, 6E) 3, 7, 11-Trimethyldodeca-2, 6, 10-Trien-1-Ol , Isolated from Launaea Pinnatifida Cass in Mice

Abstract

Cyclohexane 1,2,3,4,5 6-hexol and (2Z, 6e) 3,7, 11-trimethyldodeca-2, 6 10-trien-1-ol, isolated from Launaea Pinnatifida Cass were evaluated for their neuro pharmacological properties in mice in terms of analgesic and sedative effects. The compounds exhibited potent analgesic effect at the dose of 10 mg/kg in Eddy’s hot plate test similar to pentazocin, the standard drug. Significant sedative effect was exhibited by the test samples in mice, subjected to both the loco motor activity and marble burying activity compared with the standard drugs chlorpromazine and diazepam respectively at the dose of 10mg/kg. This study confirms at least partly the ancient use of Launaea Pinnatifida Cass as a medicine that cures neuro pharmacological disorders.