Unraveling the Cancer Metabolism: Fasting Reset, Ketogenic Diet? and Therapeutic Strategies

Abstract

Cancer cells harness a mechanism known as ketolysis to generate energy, a process that involves the enzymes SCOT and ACAT1, instrumental in the creation of a crucial molecule named acetyl-CoA. This molecule plays a vital role in cellular energy production. Interestingly, cancer cells are capable of alternative methods for generating acetyl-CoA, such as the incorporation of external acetate. Although restraining the function of SCOT and ACAT1 may decelerate cancerous growth, it could potentially impede the tumor cells’ ability to produce necessary new membranes for their survival.