Ofer Guttman, Adrien Le Thomas, S. Marsters, D. Lawrence, Lauren M. Gutgesell, Iratxe Zuazo-Gaztelu, J. Harnoss, S. M. Haag, A. Murthy, G. Strasser, Z. Modrušan, Thomas Wu, I. Mellman, A. Ashkenazi
{"title":"Antigen-derived peptides engage the ER stress sensor IRE1α to curb dendritic cell cross-presentation","authors":"Ofer Guttman, Adrien Le Thomas, S. Marsters, D. Lawrence, Lauren M. Gutgesell, Iratxe Zuazo-Gaztelu, J. Harnoss, S. M. Haag, A. Murthy, G. Strasser, Z. Modrušan, Thomas Wu, I. Mellman, A. Ashkenazi","doi":"10.1083/jcb.202111068","DOIUrl":null,"url":null,"abstract":"Antigen cross-presenting dendritic cells (DCs) activate the ER stress sensor IRE1α without ER stress. Guttman et al. show that antigen-derived ER-imported peptides can directly engage IRE1α. Regulated IRE1α-dependent MHC-I mRNA decay curbs DC cross-presentation, while IRE1α inhibition augments antitumor immunity.","PeriodicalId":343306,"journal":{"name":"The Journal of Cell Biology","volume":"20 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2022-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"13","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Journal of Cell Biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1083/jcb.202111068","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 13
Abstract
Antigen cross-presenting dendritic cells (DCs) activate the ER stress sensor IRE1α without ER stress. Guttman et al. show that antigen-derived ER-imported peptides can directly engage IRE1α. Regulated IRE1α-dependent MHC-I mRNA decay curbs DC cross-presentation, while IRE1α inhibition augments antitumor immunity.
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