Calcium ions promote migrasome formation via Synaptotagmin-1.

Yiyang Han, Li Yu
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Abstract

Migrasomes, organelles crucial for cell communication, undergo distinct stages of nucleation, maturation, and expansion. The regulatory mechanisms of migrasome formation, particularly through biological cues, remain largely unexplored. This study reveals that calcium is essential for migrasome formation. Furthermore, we identify that Synaptotagmin-1 (Syt1), a well-known calcium sensor, is not only enriched in migrasomes but also indispensable for their formation. The calcium-binding ability of Syt1 is key to initiating migrasome formation. The recruitment of Syt1 to migrasome formation sites (MFS) triggers the swelling of MFS into unstable precursors, which are subsequently stabilized through the sequential recruitment of tetraspanins. Our findings reveal how calcium regulates migrasome formation and propose a sequential interaction model involving Syt1 and Tetraspanins in the formation and stabilization of migrasomes.
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钙离子通过Synaptotagmin-1促进迁移体的形成。
移行体是对细胞通讯至关重要的细胞器,经历了独特的成核、成熟和扩展阶段。移行体形成的调控机制,尤其是通过生物线索的调控机制,在很大程度上仍未得到探索。本研究揭示了钙对移行体形成的重要性。此外,我们还发现,众所周知的钙传感器--Synaptotagmin-1(Syt1)不仅富集于迁移体中,而且对迁移体的形成也不可或缺。Syt1的钙结合能力是启动迁移体形成的关键。Syt1被招募到移行体形成位点(MFS)会引发MFS膨胀成不稳定的前体,随后通过四跨蛋白的依次招募稳定前体。我们的研究结果揭示了钙如何调控迁移体的形成,并提出了一个涉及Syt1和四跨蛋白在迁移体形成和稳定过程中的顺序相互作用模型。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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