UBAP2L ensures homeostasis of nuclear pore complexes at the intact nuclear envelope

Yongrong Liao, Leonid Andronov, Xiaotian Liu, Junyan Lin, Lucile Guerber, Linjie Lu, Arantxa Agote-Arán, Evanthia Pangou, Li Ran, Charlotte Kleiss, Mengdi Qu, Stephane Schmucker, Luca Cirillo, Zhirong Zhang, Daniel Riveline, M. Gotta, B. Klaholz, I. Sumara
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Abstract

Yongrong Liao et al. show how UBAP2L facilitates assembly and stability of mature NPCs at the nuclear envelope during early interphase to ensure efficient nuclear transport, adaptation to nutrient stress, and cellular proliferative capacity of human cells.
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UBAP2L 确保核孔复合体在完整核膜上的平衡
Yongrong Liao 等人展示了 UBAP2L 如何在间期早期促进成熟 NPC 在核膜上的组装和稳定,以确保人类细胞高效的核运输、对营养压力的适应以及细胞增殖能力。
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