Allergic Diseases

Abstract

1.4 Allergies against house dust mites (HDM), a common aeroallergen, are observed in up to 85% of asthmatic patients worldwide. HDM is an immunologically complex antigen which activates both innate and adaptive immune responses (1). Moreover it was reported that proteinases, such as trypsin-like enzymes, in HDM promoted allergenicity to proteins, resulting in allergic reactions (2). To facilitate allergic asthma research, Chondrex, Inc. provides HDM extract as a clinically relevant allergen for the induction of a mouse asthma model that mimics how asthmatic patients are sensitized with aeroallergens.