Autocorrelation Function for Predicting Arrhythmic Recurrences in Patients Undergoing Persistent Atrial Fibrillation Ablation

Abstract

Persistent atrial fibrillation ablation has a high recurrence rate. In this work, we performed an analysis of bipolar intracavitary signals obtained with a conventional 24-pole diagnostic catheter (Woven Orbiter) placed in the right atrium and coronary sinus in a cohort of patients with persistent atrial fibrillation undergoing ablation to detect features predictive of acute procedural success (conversion to sinus rhythm during ablation) and the occurrence of recurrences. The goal is to arrive at a quantitative description of the degree of randomness of the atrial response in atrial fibrillation and to demonstrate the presence of hidden periodic components. This was done by the determination of the autocorrelation function. Results showed that higher correlation in relative maximum peaks, and a lower dominant atrial frequency (greater distance between relative amplitude maxima) may be associated with a greater likelihood of achieving reversion to sinus rhythm and lower probability of recurrences. A larger study is needed to draw conclusions.