Evaluation of a porcine model for pulmonary gene transfer using a novel synthetic vector

S. Cunningham, Qing‐Hai Meng, N. Klein, R. McAnulty, S. Hart
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引用次数: 48

Abstract

The pig lung, given its gross anatomical, histological and physiological similarities to the human lung, may be useful as a large animal model, in addition to rodents, in which to assess the potential of vectors for pulmonary airway gene transfer. The aim of this study was to assess the utility of the pig lung as a model of gene transfer to the human lung with a synthetic vector system.
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新型合成载体对猪肺基因转移模型的评价
鉴于猪肺在大体解剖、组织学和生理学上与人肺相似,除啮齿类动物外,猪肺可作为大型动物模型,用于评估肺气道基因转移载体的潜力。本研究的目的是评估利用合成载体系统将猪肺作为基因转移到人肺的模型的效用。
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