Regulatory Mechanism and Application of lncRNAs in Poultry

Zhuanjian Li, T. Ren, Wenya Li, R. Han
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引用次数: 3

Abstract

Long noncoding RNA (lncRNAs) are transcripts greater than 200 nt in length with decreased coding potential and are widespread in all types of biological organisms. lncRNAs can interact with protein, DNA and RNA, respectively, which may participate in the multilevel regulation of transcriptional, posttranscriptional and epigenetic modifications. It is well known that lncRNA, which length is single-stranded non-coding RNA molecule, plays crucial roles in animal growth, development, cell proliferation and differentiation, and other life activities. In this research, we review the regulation mechanism and current research status of lncRNAs in chicken economic traits and disease, which would contribute to further understanding the regulatory mechanisms and application of lncRNAs in poultry.
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lncrna在家禽中的调控机制及应用
长链非编码RNA (Long noncoding RNA, lncRNAs)是长度大于200nt的转录本,编码潜能降低,广泛存在于所有类型的生物有机体中。lncRNAs可分别与蛋白质、DNA和RNA相互作用,参与转录、转录后和表观遗传修饰的多级调控。众所周知,长度为单链非编码RNA分子的lncRNA在动物生长发育、细胞增殖分化等生命活动中起着至关重要的作用。本文综述了lncRNAs在鸡经济性状和疾病中的调控机制及研究现状,有助于进一步了解lncRNAs在家禽中的调控机制及应用。
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