Le reali contro-indicazioni all’utilizzo della metformina

Il Diabete Pub Date : 2022-07-11 DOI:10.30682/ildia2202c
S. Piro
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Abstract

Metformin, a molecule belonging to the biguanide family, is one of the best known and most widely used drug for the management of diabetes mellitus therapy in the world. During sixty years of its use, countless benefits have been described, not only for the treatment of diabetes mellitus. However, due to sim-ilarity with other members of the drug family, concern remains high about the risk of developing lactic acidosis. This article attempts to take stock of the real risks associated with the use of metformin, trying to shed light on the real risks and the possible onset of lactic acidosis or renal damage. Metformin-induced lactic acidosis exists but is rare. Appropriate use of the drug, under safe conditions, induces benefits in the absence of risks.
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使用二甲胺的实际反指示
二甲双胍是一种双胍类分子,是目前世界上最知名、应用最广泛的糖尿病治疗药物之一。在其60年的使用中,已经描述了无数的益处,不仅仅是治疗糖尿病。然而,由于与其他药物家族成员的相似性,人们对发生乳酸酸中毒的风险仍然高度关注。本文试图评估与使用二甲双胍相关的实际风险,试图阐明实际风险以及可能发生的乳酸酸中毒或肾损害。二甲双胍引起的乳酸酸中毒是存在的,但很少见。在安全条件下适当使用该药物,在没有风险的情况下产生益处。
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