Tetra (Amidobenzylpiperidine) Cobalt (II) Phthalocyanine Based Electrochemical Sensor for the Detection of Paracetamol

Abstract

The synthesis of tetra amidobenzylpiperidine substituted Co(II) phthalocyanine (TABPCoPc) from Co(II) tetra carboxylic acid phthalocyanine (CoTcPc) via amide linkage has been developed. These macrocylic compounds are high molecular weight and sparingly soluble in common organic solvents, but soluble in aprotic organic solvents. The TABPCoPc has been confirmed by FTIR, UV-Visible X-Ray Diffraction and Thermogravimtric methods. The TABPCoPc was electrochemically active in paracetamol detection. The TABPCoPc electrode was used for detection and sensitivity of paracetamol by cyclic voltammetric method. The electrochemical analysis was done by using 0.05 M H₂SO₄ (pH-4) with TABPCoPc electrode. The linear plot observed in the concentration range of 10 µM to 180 µM with the detection limit 0.18 µM for paracetamol on the modified electrode. The TABPCoPc electrode exhibits excellent and high stability, and sensitivity for the micro molecular detection of paracetamol.