PEGylated-poly-l-lysine Dendrimers for Delivery of Chloroquine Phosphate

Abstract

The antimalarial drugs are used for prophylactic suppressive chemotherapy of malaria but various toxicity and resistance problems associated with such chemotherapy need some sustained delivery and safer carriers. Dendrimers are recently reported as carriers for various chemotherapeutic agents. Their structures are of regular repeated molecular architecture. Due to number of – NH2 group and charged species like carbonyl groups available on dendritic structures there is huge possibilities for drug loading and drug delivery and further their chemical architecture increases stability of such carriers as compared to other conventional carriers like liposomes, nanoparticles and microparticles. The present work was undertaken to solubilize and load model drug Chloroquine phosphate (CP) and reduce drawbacks of simple drug administration.