Yetmiş Beş Yaş Üstü Metastatik Mide Kanserli Hastalarda Hemoglobin, Albümin, Lenfosit, Platelet (HALP) Skoru ile Geriatrik Nütrisyonel İndeks (GNRI) ve Prognoz Arasındaki İlişki

Abstract

Aim: Gastric cancer (GC) is a common cancer with high mortality. Stage is the most important predictor of prognosis. But the clinical course of patients who are at the same stage may be different. Therefore, other prognostic markers other than stage are needed. Hemoglobin, albumin, lymphocyte and platelet (HALP) score and geriatric nutritional risk index (GNRI) related with prognosis in many malignancies, but their relationship to prognosis in patients with GC with advanced age is unknown. For this reason, we retrospectively analyzed patients older than 75 years, receiving chemotherapy, and metastatic GC. Material and Methods: We retrospectively analyzed 145 patients with metastatic gastric cancer, older than 75 years, receiving chemotherapy in secondary level state hospital between 2009 and 2022. Patients’ gender, age, Eastern Cooperative Oncology Group (ECOG) performance score, diagnosis dates, follow-up visits, albumin, hemoglobin, lactate dehydrogenase (LDH) levels, white blood cell, neutrophil, lymphocyte and platelet count, weight (kg), height (cm) values were examined. Using these values, HALP score, GNRI, and overall survival (OS) were calculated. Then, the relationship of these parameters with OS was analyzed retrospectively. Results: The median overall survival (OS) was 8.1 (95% Confidence interval (CI), 7.07 – 9.13) months. In multivariate analysis, GNRI (0.035) and HALP (p