Aim: Gastric cancer (GC) is a common cancer with high mortality. Stage is the most important predictor of prognosis. But the clinical course of patients who are at the same stage may be different. Therefore, other prognostic markers other than stage are needed. Hemoglobin, albumin, lymphocyte and platelet (HALP) score and geriatric nutritional risk index (GNRI) related with prognosis in many malignancies, but their relationship to prognosis in patients with GC with advanced age is unknown. For this reason, we retrospectively analyzed patients older than 75 years, receiving chemotherapy, and metastatic GC. Material and Methods: We retrospectively analyzed 145 patients with metastatic gastric cancer, older than 75 years, receiving chemotherapy in secondary level state hospital between 2009 and 2022. Patients’ gender, age, Eastern Cooperative Oncology Group (ECOG) performance score, diagnosis dates, follow-up visits, albumin, hemoglobin, lactate dehydrogenase (LDH) levels, white blood cell, neutrophil, lymphocyte and platelet count, weight (kg), height (cm) values were examined. Using these values, HALP score, GNRI, and overall survival (OS) were calculated. Then, the relationship of these parameters with OS was analyzed retrospectively. Results: The median overall survival (OS) was 8.1 (95% Confidence interval (CI), 7.07 – 9.13) months. In multivariate analysis, GNRI (0.035) and HALP (p
{"title":"Yetmiş Beş Yaş Üstü Metastatik Mide Kanserli Hastalarda Hemoglobin, Albümin, Lenfosit, Platelet (HALP) Skoru ile Geriatrik Nütrisyonel İndeks (GNRI) ve Prognoz Arasındaki İlişki","authors":"Serkan Menekşe, Engin Kut","doi":"10.29058/mjwbs.1198056","DOIUrl":"https://doi.org/10.29058/mjwbs.1198056","url":null,"abstract":"Aim: Gastric cancer (GC) is a common cancer with high mortality. Stage is the most important predictor \u0000of prognosis. But the clinical course of patients who are at the same stage may be different. Therefore, \u0000other prognostic markers other than stage are needed. Hemoglobin, albumin, lymphocyte and platelet \u0000(HALP) score and geriatric nutritional risk index (GNRI) related with prognosis in many malignancies, \u0000but their relationship to prognosis in patients with GC with advanced age is unknown. For this reason, \u0000we retrospectively analyzed patients older than 75 years, receiving chemotherapy, and metastatic GC. \u0000Material and Methods: We retrospectively analyzed 145 patients with metastatic gastric cancer, older \u0000than 75 years, receiving chemotherapy in secondary level state hospital between 2009 and 2022. \u0000Patients’ gender, age, Eastern Cooperative Oncology Group (ECOG) performance score, diagnosis \u0000dates, follow-up visits, albumin, hemoglobin, lactate dehydrogenase (LDH) levels, white blood cell, \u0000neutrophil, lymphocyte and platelet count, weight (kg), height (cm) values were examined. Using these \u0000values, HALP score, GNRI, and overall survival (OS) were calculated. Then, the relationship of these \u0000parameters with OS was analyzed retrospectively. \u0000Results: The median overall survival (OS) was 8.1 (95% Confidence interval (CI), 7.07 – 9.13) months. \u0000In multivariate analysis, GNRI (0.035) and HALP (p","PeriodicalId":309460,"journal":{"name":"Medical Journal of Western Black Sea","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123036705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ş. Öztürk, Y. Hazer, Banu Kaskatepe, H. Çölgeçen, M. Kulak
Amaç: Bu çalışmada, Kırmızı Kantaron, Hypericum capitatum var. capitatum (H. capitatum) bitkisinin fenolik içeriğinin ve antioksidan aktivitesinin belirlenmesi, standart suşlar ve klinik izolatlar üzerinde antimikrobiyal etkisinin araştırılması amaçlanmıştır. Gereç ve Yöntemler: H. capitatum’un, standart bakteri suşları ile kolistin dirençli Acinetobacter baumannii (A. baumannii) ve çok ilaca dirençli (ÇİD) A. baumannii klinik izolatları üzerindeki antimikrobiyal etki düzeylerine sıvı mikrodilüsyon testi (MİK) ile gerçekleştirilmiştir (ISO, 2006). Yüksek Performanslı Sıvı Kromatografisi (YPSK) ile bazı içerikleri aydınlatılan H. capitatum ekstraktının, tohum, gövde ve yaprak örneklerinde total fenol içeriği araştırılmıştır. DPPH (2,2-difenil-1-pikrilhidrazil) yöntemi ile antioksidan etkinlik tayini yapılmıştır. Bulgular: Metanolle ekstrakte edilen bitkinin, Gram (+) bakterilere karşı Staphylococcus aureus (S.aureus) ATCC-29213 ve Metisilin dirençli S. aureus (MRSA) ATCC 43300 antimikrobiyal etkinliğinin 16 (mg/mL) olduğu saptanmıştır. Dirençli A. baumannii klinik izolatlarına karşı, 64-128 mg/mL MİK değerleri ile etkin olduğu tespit edilmiştir. YPSK ile bitkinin tohum kısmındaki içerikler ise, sırasıyla; şikimik asit (1720.42 ppm(mg/ml), kafeik asit (52.50 ppm(mg/ml), sinaminik asit, (14.217,61 ppm(mg/ml), rosmarinik asit (30,90 ppm(mg/ml) olarak belirlenmiştir. H. capitatum kısımlarına göre toplam fenolik madde miktarlarının, yaprak (155,93 mg/L), gövde (177,85 mg/L) ve tohum (344,22 mg/L) şeklinde farklılık gösterdiği tespit edilmiştir. DPPH İnhibisyon aktivitesi; tohum (%55.476 mg/mL), gövde (%57.318 mg/ ml), yaprak (%53.241 mg/ml) BHA (Butil hidroksi anozil) ve BHT (Butil hidroksi tolüen) sırasıyla (%93.77 ve %88.62) askorbik asit ise (%95.21) olarak belirlenmiştir. Sonuç: Fenolik içerikçe zengin olduğu görülen H. capitatum’ un, antioksidan etkinlik sonuçları, farklı kısımlarının metanol ekstreleri orta derecede etkili serbest radikal gideren doğal bir antioksidan kaynağı olduğunu göstermiştir. Antimikrobiyal etkinlik sonuçları ise, standart suşlar ve özellikle klinikte tedavisinin zor olduğu bilinen dirençli A. baumannii izolatlarına karşı etkinliğinin umut vaat edici olduğu görülmüştür.
{"title":"Red Centaury (Hypericum capitatum): Determination of Phenolic Content, Antioxidant Activity and Investigation of Antimicrobial Efficacy on Clinical Isolates","authors":"Ş. Öztürk, Y. Hazer, Banu Kaskatepe, H. Çölgeçen, M. Kulak","doi":"10.29058/mjwbs.1251370","DOIUrl":"https://doi.org/10.29058/mjwbs.1251370","url":null,"abstract":"Amaç: Bu çalışmada, Kırmızı Kantaron, Hypericum capitatum var. capitatum (H. capitatum) bitkisinin \u0000fenolik içeriğinin ve antioksidan aktivitesinin belirlenmesi, standart suşlar ve klinik izolatlar üzerinde \u0000antimikrobiyal etkisinin araştırılması amaçlanmıştır. \u0000Gereç ve Yöntemler: H. capitatum’un, standart bakteri suşları ile kolistin dirençli Acinetobacter \u0000baumannii (A. baumannii) ve çok ilaca dirençli (ÇİD) A. baumannii klinik izolatları üzerindeki \u0000antimikrobiyal etki düzeylerine sıvı mikrodilüsyon testi (MİK) ile gerçekleştirilmiştir (ISO, 2006). Yüksek \u0000Performanslı Sıvı Kromatografisi (YPSK) ile bazı içerikleri aydınlatılan H. capitatum ekstraktının, tohum, \u0000gövde ve yaprak örneklerinde total fenol içeriği araştırılmıştır. DPPH (2,2-difenil-1-pikrilhidrazil) yöntemi \u0000ile antioksidan etkinlik tayini yapılmıştır. \u0000Bulgular: Metanolle ekstrakte edilen bitkinin, Gram (+) bakterilere karşı Staphylococcus aureus (S.aureus) \u0000ATCC-29213 ve Metisilin dirençli S. aureus (MRSA) ATCC 43300 antimikrobiyal etkinliğinin 16 \u0000(mg/mL) olduğu saptanmıştır. Dirençli A. baumannii klinik izolatlarına karşı, 64-128 mg/mL MİK değerleri \u0000ile etkin olduğu tespit edilmiştir. YPSK ile bitkinin tohum kısmındaki içerikler ise, sırasıyla; şikimik asit \u0000(1720.42 ppm(mg/ml), kafeik asit (52.50 ppm(mg/ml), sinaminik asit, (14.217,61 ppm(mg/ml), rosmarinik \u0000asit (30,90 ppm(mg/ml) olarak belirlenmiştir. H. capitatum kısımlarına göre toplam fenolik madde \u0000miktarlarının, yaprak (155,93 mg/L), gövde (177,85 mg/L) ve tohum (344,22 mg/L) şeklinde farklılık \u0000gösterdiği tespit edilmiştir. DPPH İnhibisyon aktivitesi; tohum (%55.476 mg/mL), gövde (%57.318 mg/ \u0000ml), yaprak (%53.241 mg/ml) BHA (Butil hidroksi anozil) ve BHT (Butil hidroksi tolüen) sırasıyla (%93.77 \u0000ve %88.62) askorbik asit ise (%95.21) olarak belirlenmiştir. \u0000Sonuç: Fenolik içerikçe zengin olduğu görülen H. capitatum’ un, antioksidan etkinlik sonuçları, farklı \u0000kısımlarının metanol ekstreleri orta derecede etkili serbest radikal gideren doğal bir antioksidan kaynağı \u0000olduğunu göstermiştir. Antimikrobiyal etkinlik sonuçları ise, standart suşlar ve özellikle klinikte tedavisinin \u0000zor olduğu bilinen dirençli A. baumannii izolatlarına karşı etkinliğinin umut vaat edici olduğu görülmüştür.","PeriodicalId":309460,"journal":{"name":"Medical Journal of Western Black Sea","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127785092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aim: The aim of this study is to examine the effect of the dyspnea on cognitive status in patients with chronic obstructive pulmonary diseases (COPD). Material and Methods: The universe of this descriptive study consist of 315 COPD patients. Data were collected with a Questionare, Medical Research Council Scale (MRCS) and Standardize Mini Mental State Examination (SMMT-E). In the analyses of the data, descriptive statistics, independent t-test, oneway analysis of variance and regression and Tamhane T2 analysis were employed. Results: The mean age of the patients patricipating the study was 54.06 (11.41) years. 38% of the patients were determined to experienced moderate dyspnea (2.20±0.95). The patients’ cognitive status mean scores were found low (21.38±5.74) and 58.7% had cognitive impairment. It was determined in multiple regression analysis that severe dyspnea level, inadequacy in dyspnea management, associating dyspnea with breathlessness, feeling of low mood and fear of death, use of oxygen tube and bipod at home were associated with cognitive status. Moreover, it was found that 31% of the variance in the cognitive level of the patients was explained by the independent variables related to dyspnea (R2 = 0.581; adjusted R2= 0.311). It was found that there was a strong positive correlation between dyspnea and cognition status (r=-0.705, p=0.000). Conclusion: It was determined that dyspnea effects to SMMT-E and therefore it could be advised to taking measures to reduce dyspnea COPD patients.
{"title":"Kronik Obstrüktif Akciğer Hastalığı (KOAH) Olanlarda Dispnenin Bilişsel Duruma Etkisi","authors":"Döndü Şanlitürk, Nurgül Kaplan","doi":"10.29058/mjwbs.1174031","DOIUrl":"https://doi.org/10.29058/mjwbs.1174031","url":null,"abstract":"Aim: The aim of this study is to examine the effect of the dyspnea on cognitive status in patients with \u0000chronic obstructive pulmonary diseases (COPD). \u0000Material and Methods: The universe of this descriptive study consist of 315 COPD patients. Data were \u0000collected with a Questionare, Medical Research Council Scale (MRCS) and Standardize Mini Mental \u0000State Examination (SMMT-E). In the analyses of the data, descriptive statistics, independent t-test, oneway \u0000analysis of variance and regression and Tamhane T2 analysis were employed. \u0000Results: The mean age of the patients patricipating the study was 54.06 (11.41) years. 38% of the \u0000patients were determined to experienced moderate dyspnea (2.20±0.95). The patients’ cognitive status \u0000mean scores were found low (21.38±5.74) and 58.7% had cognitive impairment. It was determined \u0000in multiple regression analysis that severe dyspnea level, inadequacy in dyspnea management, \u0000associating dyspnea with breathlessness, feeling of low mood and fear of death, use of oxygen tube and \u0000bipod at home were associated with cognitive status. Moreover, it was found that 31% of the variance in \u0000the cognitive level of the patients was explained by the independent variables related to dyspnea (R2 = \u00000.581; adjusted R2= 0.311). It was found that there was a strong positive correlation between dyspnea \u0000and cognition status (r=-0.705, p=0.000). \u0000Conclusion: It was determined that dyspnea effects to SMMT-E and therefore it could be advised to \u0000taking measures to reduce dyspnea COPD patients.","PeriodicalId":309460,"journal":{"name":"Medical Journal of Western Black Sea","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122916824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aim: This study was conducted to examine the relationship between computer addiction (computer, internet, game addiction) and adolescent problems in Turkish generation K adolescents with correlation analysis. Material and Methods: This study is a cross-sectional study. This research was carried out in three high schools in the city center of a city selected according to their success ranking in the high school entrance exam. In the study, a total of 665 students who received parental and student permission were included. Adolescents’ Computer (computer/internet/game) Addiction Scale and Adolescence Problems Scanning List were used to gathering data. In the study, subscales of computer addiction scale for adolescence (computer, internet, game) were determined as Set 1, and subscales of adolescence problems scanning list (physical, social, relationship with the opposite sex and sexual information, psychological, future expectations) were determined as Set 2. Expected relationships between these Set 1 and Set 2 explained in an efficient manner by canonical weights and loadings. Results: Three canonical variate pairs were ranging from 0.688 to 0.150. It was observed that the first and the second pairs were significant (p
{"title":"Examining the Relationship between Adolescence Problems and Computer (Computer, Internet, Game) Addiction with Canonic Correlation Analysis in Turkish Generation K Adolescents: Ordu Province Center (Altinordu) Example","authors":"Nevin Günaydın, Yeliz Kaşko Arıcı","doi":"10.29058/mjwbs.1098894","DOIUrl":"https://doi.org/10.29058/mjwbs.1098894","url":null,"abstract":"Aim: This study was conducted to examine the relationship between computer addiction (computer, \u0000internet, game addiction) and adolescent problems in Turkish generation K adolescents with correlation \u0000analysis. \u0000Material and Methods: This study is a cross-sectional study. This research was carried out in three \u0000high schools in the city center of a city selected according to their success ranking in the high school \u0000entrance exam. In the study, a total of 665 students who received parental and student permission were \u0000included. Adolescents’ Computer (computer/internet/game) Addiction Scale and Adolescence Problems \u0000Scanning List were used to gathering data. In the study, subscales of computer addiction scale for \u0000adolescence (computer, internet, game) were determined as Set 1, and subscales of adolescence \u0000problems scanning list (physical, social, relationship with the opposite sex and sexual information, \u0000psychological, future expectations) were determined as Set 2. Expected relationships between these \u0000Set 1 and Set 2 explained in an efficient manner by canonical weights and loadings. \u0000Results: Three canonical variate pairs were ranging from 0.688 to 0.150. It was observed that the \u0000first and the second pairs were significant (p","PeriodicalId":309460,"journal":{"name":"Medical Journal of Western Black Sea","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130470713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Amaç: Helicobacter pylori (H. pylori) gastroduodenal inflamasyon, ülser ve atrofik gastrite yol açan bakteriyel bir patojendir. Mikronüklus (MN)’ lar hücrenin mitoz bölünmesi sırasında ortaya çıkan esas çekirdeğe dahil olmayan oluşumlardır. Bu çalışmada, H. pylori ile mikronükleer ve binükleer hücre arasındaki ilişkinin eksfolyatif sitoloji yöntemi ile değerlendirilmesi amaçlanmıştır. Gereç ve Yöntemler: Bu çalışmada Zonguldak Bülent Ecevit Üniversitesi Uygulama ve Araştırma Hastanesi Çocuk Gastroenteroloji polikliniğine yaşam kalitesini etkileyecek tarzda ciddi dispeptik yakınmalarla başvuran ve endoskopik biyopsi yapılan hastalar yer aldı. Biyopsi örnekleri formalinde fikse edildi ve parafin bloklardan hazırlanan kesitler Hematoksilen & Eozin (H&E) ile boyandı. H. pylori varlığı açısından ışık mikroskobik olarak değerlendirildi. Biyopsi sonucu sadece H. pylori pozitif örnekler çalışma grubu (n=30) hiçbir enfeksiyon etkeni saptanmayanlar ise kontrol grubu (n=30) olarak alındı. Tüm hastalardan alınan yanak epitel hücreleri lamlara yayıldı, % 95’lik etil alkolde fikse edildi ve Papanicolaou boyama yöntemine göre boyandı. Mikronükleer ve binükleer hücreler iyi boyanmış 1000 epitel hücrede sayıldı. İstatistiksel değerlendirme SPSS 18.0 (SPSS Inc., Chicago, IL, USA) programı kullanıldı ve p
{"title":"Evaluation of Micronucleer and Binucleer Cells Frequencies in Buccal Epithelial Cells of Children Infected with Helicobacter pylori","authors":"Zehra SAFİ ÖZ, Gonca Handan ŞAHAN ÜSTÜNDAĞ, Halime TOPUZ ALTUNTAŞ, Nilüfer ONAK KANDEMİR","doi":"10.29058/mjwbs.1205737","DOIUrl":"https://doi.org/10.29058/mjwbs.1205737","url":null,"abstract":"Amaç: Helicobacter pylori (H. pylori) gastroduodenal inflamasyon, ülser ve atrofik gastrite yol açan \u0000bakteriyel bir patojendir. Mikronüklus (MN)’ lar hücrenin mitoz bölünmesi sırasında ortaya çıkan esas \u0000çekirdeğe dahil olmayan oluşumlardır. Bu çalışmada, H. pylori ile mikronükleer ve binükleer hücre \u0000arasındaki ilişkinin eksfolyatif sitoloji yöntemi ile değerlendirilmesi amaçlanmıştır. \u0000Gereç ve Yöntemler: Bu çalışmada Zonguldak Bülent Ecevit Üniversitesi Uygulama ve Araştırma \u0000Hastanesi Çocuk Gastroenteroloji polikliniğine yaşam kalitesini etkileyecek tarzda ciddi dispeptik \u0000yakınmalarla başvuran ve endoskopik biyopsi yapılan hastalar yer aldı. Biyopsi örnekleri formalinde \u0000fikse edildi ve parafin bloklardan hazırlanan kesitler Hematoksilen & Eozin (H&E) ile boyandı. H. \u0000pylori varlığı açısından ışık mikroskobik olarak değerlendirildi. Biyopsi sonucu sadece H. pylori pozitif \u0000örnekler çalışma grubu (n=30) hiçbir enfeksiyon etkeni saptanmayanlar ise kontrol grubu (n=30) olarak \u0000alındı. Tüm hastalardan alınan yanak epitel hücreleri lamlara yayıldı, % 95’lik etil alkolde fikse edildi ve \u0000Papanicolaou boyama yöntemine göre boyandı. Mikronükleer ve binükleer hücreler iyi boyanmış 1000 \u0000epitel hücrede sayıldı. İstatistiksel değerlendirme SPSS 18.0 (SPSS Inc., Chicago, IL, USA) programı \u0000kullanıldı ve p","PeriodicalId":309460,"journal":{"name":"Medical Journal of Western Black Sea","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123035276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aim: The study’s aim is to evaluate mean platelet volume (MPV) as a marker of inflammation in patients with acute pancreatitis (AP) and to analyse the relationships among MPV, CRP (C-reactive protein) and Ranson’s score. Material and Methods: In this study, 119 patients with AP (mean age 53.8 ± 18.0 years) and 88 healthy control group (mean age 53.1 ± 6.8 years) were enrolled. Among the patients with AP, 75 were classified as having biliary AP, and 44 were classified as having nonbiliary AP. All patients’ demographic data, clinical and laboratory findings and Ranson’s scores were examined from the hospital’s database. Results: MPV was significantly lower among patients with AP than among the control group (p = 0.001). CRP was significantly higher among patients with AP than among the control group (p< 0.001). The difference in MPV between the biliary and nonbiliary AP group was statistically not significant. When we compared MPV based on patients’ lengths of hospital stay, there was no significant difference. In correlation analysis, there was no correlation among CRP, Ranson’s score and serum MPV levels. Conclusion: We observed that MPV levels in the AP group were lower than healthy controls. Thus, like other inflammation markers, MPV might be a useful marker for AP diagnosis.
{"title":"Akut Pankreatitte Yeni Bir İnflamatuar Belirteç Olarak Ortalama Trombosit Hacmi ve C-Reaktif Protein ile Başvuru Anındaki Ranson Skoru ile İlişkisi","authors":"Baris Karagün, Tayyibe Saler","doi":"10.29058/mjwbs.1228491","DOIUrl":"https://doi.org/10.29058/mjwbs.1228491","url":null,"abstract":"Aim: The study’s aim is to evaluate mean platelet volume (MPV) as a marker of inflammation in patients \u0000with acute pancreatitis (AP) and to analyse the relationships among MPV, CRP (C-reactive protein) and \u0000Ranson’s score. \u0000Material and Methods: In this study, 119 patients with AP (mean age 53.8 ± 18.0 years) and 88 healthy \u0000control group (mean age 53.1 ± 6.8 years) were enrolled. Among the patients with AP, 75 were classified \u0000as having biliary AP, and 44 were classified as having nonbiliary AP. All patients’ demographic data, \u0000clinical and laboratory findings and Ranson’s scores were examined from the hospital’s database. \u0000Results: MPV was significantly lower among patients with AP than among the control group (p = 0.001). \u0000CRP was significantly higher among patients with AP than among the control group (p< 0.001). The \u0000difference in MPV between the biliary and nonbiliary AP group was statistically not significant. When \u0000we compared MPV based on patients’ lengths of hospital stay, there was no significant difference. In \u0000correlation analysis, there was no correlation among CRP, Ranson’s score and serum MPV levels. \u0000Conclusion: We observed that MPV levels in the AP group were lower than healthy controls. Thus, like \u0000other inflammation markers, MPV might be a useful marker for AP diagnosis.","PeriodicalId":309460,"journal":{"name":"Medical Journal of Western Black Sea","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121413024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aim: Neck pain is one of the most prevalent medical complaints. Chronic pain conditions can lead to depression, anxiety and sleep problems in individuals. Thus, both the pain itself and the psychiatric problems it causes impair the quality of life of the patient. Depression and anxiety can also cause changes in the perception of pain. In this study, we aimed to investigate the effects of cervical disc herniation (CDH), which causes chronic neck pain, on the level of neck disability, sleep quality, anxiety and depression. Material and Methods: Patients’ pain intensity, neck disability indexes, depression and anxiety status, and sleep quality were evaluated using a visual analog scale (VAS), the neck disability index (NDI), Beck Depression Inventory (BDI), beck anxiety inventory (BAI) and the Pittsburgh Sleep Quality Index (PSQI), respectively. Results: We found a statistically significant relationship between CDH and anxiety, depression and sleep quality. In addition, we found higher levels of pain, anxiety and depression in the group with poor sleep quality. Conclusion: For optimal treatment approaches of patients with chronic neck pain, accompanying sleep disorder, depression and anxiety should also be evaluated.
{"title":"Evaluation of Depression, Anxiety and Sleep Quality Scores in Patients with Cervical Disc Herniation: A Study Conducted in Turkey","authors":"A. Uysal, Murat Güntel","doi":"10.29058/mjwbs.1220876","DOIUrl":"https://doi.org/10.29058/mjwbs.1220876","url":null,"abstract":"Aim: Neck pain is one of the most prevalent medical complaints. Chronic pain conditions can lead to \u0000depression, anxiety and sleep problems in individuals. Thus, both the pain itself and the psychiatric \u0000problems it causes impair the quality of life of the patient. Depression and anxiety can also cause changes \u0000in the perception of pain. In this study, we aimed to investigate the effects of cervical disc herniation (CDH), \u0000which causes chronic neck pain, on the level of neck disability, sleep quality, anxiety and depression. \u0000Material and Methods: Patients’ pain intensity, neck disability indexes, depression and anxiety status, \u0000and sleep quality were evaluated using a visual analog scale (VAS), the neck disability index (NDI), \u0000Beck Depression Inventory (BDI), beck anxiety inventory (BAI) and the Pittsburgh Sleep Quality Index \u0000(PSQI), respectively. \u0000Results: We found a statistically significant relationship between CDH and anxiety, depression and sleep \u0000quality. In addition, we found higher levels of pain, anxiety and depression in the group with poor sleep \u0000quality. \u0000Conclusion: For optimal treatment approaches of patients with chronic neck pain, accompanying sleep \u0000disorder, depression and anxiety should also be evaluated.","PeriodicalId":309460,"journal":{"name":"Medical Journal of Western Black Sea","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116410531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Burak Acem, Merve Osoydan Satici, S. Özdemir, S. Eroğlu
Amaç: Brugada sendromunun hızlı ve doğru teşhisi, semptomatik hastalarda aritmiden kaynaklanan ani kardiyak ölüm riskinin yüksek olması nedeniyle çok önemlidir. Acil serviste Tip 2 Brugada EKG paterni tespit edilen bir olguyu, klinik tanı güçlüğü ve nadir görülmesi sebebi ile sunmayı ve tartışmayı amaçladık. Olgu: Kırkdokuz yaşında erkek hasta acil servise 45 dakika önce başlayan sol göğüste ve epigastrik bölgede lokalize sıkıştırıcı tarzda göğüs ağrısıyla başvurdu. Tekrarlayan senkop öyküsü, ailede erken ölüm hikâyesi mevcuttu. Hız kontrolü sağlandıktan sonra çekilen EKG’sinde kalp tepe atımı 99/dk, V1- V2 derivasyonlarında ST segmentinde elevasyonu takiben 1mm’den fazla çökme ile karakterize ‘eğer tipi’ görünüm tespit edildi. Sonuç: Tip 1 Brugada paterni olan hastalara göre ani kardiyak ölüm açısından daha az riskli olarak kabul edilse de BrS EKG’si dinamik ve değişkendir, Tip 2 kısa sürede Tip 1’e dönüşebilir; bu nedenle gözden kaçırılmamalıdır
{"title":"An Important Risk Factor for Sudden Cardiac Death: Type 2 Brugada Syndrome","authors":"Burak Acem, Merve Osoydan Satici, S. Özdemir, S. Eroğlu","doi":"10.29058/mjwbs.1209412","DOIUrl":"https://doi.org/10.29058/mjwbs.1209412","url":null,"abstract":"Amaç: Brugada sendromunun hızlı ve doğru teşhisi, semptomatik hastalarda aritmiden kaynaklanan \u0000ani kardiyak ölüm riskinin yüksek olması nedeniyle çok önemlidir. Acil serviste Tip 2 Brugada EKG \u0000paterni tespit edilen bir olguyu, klinik tanı güçlüğü ve nadir görülmesi sebebi ile sunmayı ve tartışmayı \u0000amaçladık. \u0000Olgu: Kırkdokuz yaşında erkek hasta acil servise 45 dakika önce başlayan sol göğüste ve epigastrik \u0000bölgede lokalize sıkıştırıcı tarzda göğüs ağrısıyla başvurdu. Tekrarlayan senkop öyküsü, ailede erken \u0000ölüm hikâyesi mevcuttu. Hız kontrolü sağlandıktan sonra çekilen EKG’sinde kalp tepe atımı 99/dk, V1- \u0000V2 derivasyonlarında ST segmentinde elevasyonu takiben 1mm’den fazla çökme ile karakterize ‘eğer \u0000tipi’ görünüm tespit edildi. \u0000Sonuç: Tip 1 Brugada paterni olan hastalara göre ani kardiyak ölüm açısından daha az riskli olarak \u0000kabul edilse de BrS EKG’si dinamik ve değişkendir, Tip 2 kısa sürede Tip 1’e dönüşebilir; bu nedenle \u0000gözden kaçırılmamalıdır","PeriodicalId":309460,"journal":{"name":"Medical Journal of Western Black Sea","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129520991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aim: The aim of our study is to analyze the SIRT1 gene rs2273773, rs7895833 and rs7069102 polymorphisms and the association of SIRT1 gene and interacting genes with vitiligo disease by molecular and in silico methods. Material and Methods: The study group consisted of 78 vitiligo patients and 85 unrelated healthy controls. SIRT1 polymorphisms were determined using the Polymerase chain reaction confronting twopair primers (PCR-CTPP) method. In addition, other genes with which the SIRT1 gene interacts and gene ontology (GO) were determined using the GeneMANIA and GeneCodis 4 tools, respectively. Results: We have determined a significant difference in genotypes of rs7895833 in SIRT1 gene. Especially, the AG genotype was observed more in the group with vitiligo. It was determined that the rs7895833 G allele had a protective effect in terms of vitiligo (p=0.001). Intergene interaction analysis was also performed by in silico method, and it was shown that SIRT 1 is co-expressed with 16 genes and shares an area with only 12 genes physically interacting with 19 genes. We showed gene ontology and pathway analyzed with all relevant genes. It was determined that especially apoptosis and systemic sclerosis were associated with these genes. Conclusion: The SIRT1 rs7895833 SNP genotype and allele frequencies of vitiligo patients are significantly different from healthy controls. Our study shows that the rs7895833 polymorphism of the SIRT1 gene may be associated with vitiligo susceptibility. Considering the role of sirtuin and related genes, especially in the apoptotic pathway, its effect on vitiligo can be further investigated to elucidate the molecular aspect of the disease.
{"title":"SIRT1 Gen Polimorfizmleri ve Vitiligo Riski İlişkisi: Moleküler ve “in Siliko” Yaklaşım","authors":"Oktay Kuru, Nilgün SOLAK TEKİN, Ümmühani ÖZEL TÜRKCÜ, Sevim KARAKAŞ ÇELİK, Tuba Edgünlü","doi":"10.29058/mjwbs.1223300","DOIUrl":"https://doi.org/10.29058/mjwbs.1223300","url":null,"abstract":"Aim: The aim of our study is to analyze the SIRT1 gene rs2273773, rs7895833 and rs7069102 \u0000polymorphisms and the association of SIRT1 gene and interacting genes with vitiligo disease by \u0000molecular and in silico methods. \u0000Material and Methods: The study group consisted of 78 vitiligo patients and 85 unrelated healthy \u0000controls. SIRT1 polymorphisms were determined using the Polymerase chain reaction confronting twopair \u0000primers (PCR-CTPP) method. In addition, other genes with which the SIRT1 gene interacts and \u0000gene ontology (GO) were determined using the GeneMANIA and GeneCodis 4 tools, respectively. \u0000Results: We have determined a significant difference in genotypes of rs7895833 in SIRT1 gene. \u0000Especially, the AG genotype was observed more in the group with vitiligo. It was determined that the \u0000rs7895833 G allele had a protective effect in terms of vitiligo (p=0.001). Intergene interaction analysis \u0000was also performed by in silico method, and it was shown that SIRT 1 is co-expressed with 16 genes \u0000and shares an area with only 12 genes physically interacting with 19 genes. We showed gene ontology \u0000and pathway analyzed with all relevant genes. It was determined that especially apoptosis and systemic \u0000sclerosis were associated with these genes. \u0000Conclusion: The SIRT1 rs7895833 SNP genotype and allele frequencies of vitiligo patients are \u0000significantly different from healthy controls. Our study shows that the rs7895833 polymorphism of the \u0000SIRT1 gene may be associated with vitiligo susceptibility. Considering the role of sirtuin and related \u0000genes, especially in the apoptotic pathway, its effect on vitiligo can be further investigated to elucidate \u0000the molecular aspect of the disease.","PeriodicalId":309460,"journal":{"name":"Medical Journal of Western Black Sea","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125258270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aim: Subacute thyroiditis (SAT) is a thyroid disease that seriously affects the quality of life for patients caused by acute inflammation of the thyroid gland. Apart from classical acute phase reactants, the values and rates obtained from peripheral blood count (mean platelet volume (MPV), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR)) values are also accepted as practical indicators of systemic inflammation. Our aim in this study is to compare the effects of systemic inflammation markers and the treatments given in the laboratory tests of our patients with a diagnosis of SAT, on the hypothyroid state one year later. Material and Methods: In this study, which was carried out with a retrospective method, 133 patients were included in the study. The medical data of these patients at the time of SAT diagnosis and one year later were analyzed. 37 patients were in the steroid group and 97 patients were in the nonsteroidal anti-inflammatory drug (NSAID) group. Results: The male/female ratio was similar in both groups. Female dominance was observed in both groups in patients diagnosed with SAT. The thyroid tests of the groups, which were hyperthyroid at the beginning and euthyroid one year later, were similar between the groups (p>0.05). Both groups had an increase in acute phase reactants at baseline (erythrocyte sedimentation rate [ESR] and C-reactive protein (CRP) levels) and normalized after treatment. Neutrophil (p0.05) and platelet (p0.05). Conclusion: Inflammation markers and treatments applied in SAT patients did not have a significant effect on the prognosis
{"title":"Subakut Tiroiditte Prognoz Öngörülebilir mi?","authors":"Ali Saklamaz, Özcan Çi̇ftçi̇","doi":"10.29058/mjwbs.1221562","DOIUrl":"https://doi.org/10.29058/mjwbs.1221562","url":null,"abstract":"Aim: Subacute thyroiditis (SAT) is a thyroid disease that seriously affects the quality of life for patients \u0000caused by acute inflammation of the thyroid gland. Apart from classical acute phase reactants, the values \u0000and rates obtained from peripheral blood count (mean platelet volume (MPV), neutrophil-to-lymphocyte \u0000ratio (NLR), and platelet-to-lymphocyte ratio (PLR)) values are also accepted as practical indicators \u0000of systemic inflammation. Our aim in this study is to compare the effects of systemic inflammation \u0000markers and the treatments given in the laboratory tests of our patients with a diagnosis of SAT, on the \u0000hypothyroid state one year later. \u0000Material and Methods: In this study, which was carried out with a retrospective method, 133 patients \u0000were included in the study. The medical data of these patients at the time of SAT diagnosis and one \u0000year later were analyzed. 37 patients were in the steroid group and 97 patients were in the nonsteroidal \u0000anti-inflammatory drug (NSAID) group. \u0000Results: The male/female ratio was similar in both groups. Female dominance was observed in both \u0000groups in patients diagnosed with SAT. The thyroid tests of the groups, which were hyperthyroid at the \u0000beginning and euthyroid one year later, were similar between the groups (p>0.05). Both groups had \u0000an increase in acute phase reactants at baseline (erythrocyte sedimentation rate [ESR] and C-reactive \u0000protein (CRP) levels) and normalized after treatment. Neutrophil (p0.05) and \u0000platelet (p0.05). \u0000Conclusion: Inflammation markers and treatments applied in SAT patients did not have a significant \u0000effect on the prognosis","PeriodicalId":309460,"journal":{"name":"Medical Journal of Western Black Sea","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126634170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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