Polarization interference mapping of microscopic images of protein fluorofores in the differential diagnosis of benign and malignant prostate tumours

Abstract

The paper presents the results of the possibility of a polarization-interference approach to the analysis of microscopic images of biological preparations in the differential diagnosis [1-7] of benign and malignant prostate tumors with different degrees of differentiation. Measurements and analysis of maps and histograms of the distribution of the local contrast value of polarization-interference distributions of microscopic images of biological preparations of the prostate. Determination of the relationship between the statistical moments of the 1st - 4th orders, characterizing the distributions of the value of the local contrast of polarization-interference distributions of microscopic images of biological preparations of the prostate [8-12]. Determination of statistical criteria for polarization-interference diagnosis of histological sections of biopsy of adenoma and adenocarcinoma of the prostate with varying degrees of differentiation. Determination of operational characteristics (sensitivity, specificity, accuracy) of the diagnostic power [13-19] of the polarization interferometry method for differential diagnosis of histological sections of biopsy of adenoma and adenocarcinoma of the prostate with varying degrees of differentiation.