Effect of Titanium Dioxide Nanoparticles (TiO2NPs) on Leishmania parasite in vitro

Abstract

The study included detecting the effect of nanoparticles of titanium dioxide nanoparticles (TiO2NPs) with different concentrations (0.5, 1, 5, 10) mg/ml and for two sizes (100, 10) nm on parasites of Leishmania tropica in vitro. The results showed that titanium dioxide nanoparticles (TiO2NPs) have an effect on the parasite with an inverse relationship between growth rate, concentrations of nanoparticles and the exposure period as well as the size of the nanoparticles. The sizes used of titanium dioxide nanoparticles (TiO2NPs) with all their concentrations had a toxic effect on Leishmania promastigote developing in culture media at 48 and 72 hours compared to the control group and that the concentrations of size 10 nm were more effective than concentrations of size of 100 nm on the growth of the parasite during the same time peroids used, and this gives an indication of the importance of using small sizes of titanium dioxide nanoparticles (TiO2NPs) as an anti-growth of Leishmania parasites.