Effetti pleiotropici della metformina: hanno rilevanza clinica?

Il Diabete Pub Date : 2022-07-11 DOI:10.30682/ildia2202b
G. Sesti
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Abstract

Sixty years after its introduction in the therapeutic arsenal of type 2 diabetes, metformin remains the first-line treatment of type 2 diabetes according to national and international guidelines. Numerous obser¬vational studies have suggested that metformin may exert beneficial therapeutic effects on diabetes - and nondiabetes - related comorbidi¬ties, including cardiovascular, hepatic, neoplastic, and infectious dis¬eases. However, direct evidence of the pleiotropic effects of metformin from specific randomized controlled trials is still lacking.
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胸膜偏二胺的作用:它们有临床意义吗?
在二甲双胍被引入2型糖尿病治疗库60年后,根据国家和国际指南,二甲双胍仍然是2型糖尿病的一线治疗药物。许多观察性研究表明,二甲双胍可能对糖尿病和非糖尿病相关的合并症(包括心血管、肝脏、肿瘤和传染病)发挥有益的治疗作用。然而,从特定的随机对照试验中仍然缺乏二甲双胍多效作用的直接证据。
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