Concentrated growth factors in the treatment of adjacent multiple gingival recessions: A split-mouth randomized control trial

Abstract

: The aim of this study was to determine the clinical effect of Concentrated Growth Factor (CGF) in combination with Coronally Advanced Flap (CAF) compared to CAF alone in the treatment of adjacent multiple Miller’s Class I GRs. A total of 10 patients with Class I Miller’s recession were randomly assigned by a coin toss method as Group I which received Coronally Advanced Flap alone (CAF) and Group II which received Coronally Advanced Flap (CAF) with Concentrated Growth Factor (CGF). The clinical parameters such as, Recession Height (RH), Recession Width (RW), Probing Pocket Depth (PPD), Clinical Attachment Level (CAL), Keratinized Tissue Width (KTW) and Thickness of Keratinized Tissue (TKT) were measured at baseline and 3 months postoperatively. The Mean Root Coverage (MRC), Complete Root Coverage (CRC) and Root coverage Esthetic Score (RES) were measured after 3 months postoperatively. Statistically significant difference in RH, RW, CAL, KTW, TKT, MRC and RES were observed on comparison of Group I and Group II at 3 months. On comparison, of Group I and Group II, no statistically significant difference was seen in PPD and CRC between the groups at 3 months.The present study indicates that CAF with a CGF proved to be superior. The KTW and TKT augmentation might improve the long-term predictability of the root coverage procedures, hence the use of CGF combined with CAF, diminishes post-surgical relapse and thus providing long-term stability.