The Germinative Preponderance-Sebaceous Epithelioma

Abstract

Sebaceous epithelioma is a benign, exceptional, distinctive neoplasm comprised of basaloid cells and mature sebocytes. Although a sporadic neoplasm, Muir-Torre syndrome can be frequently associated with sebaceous epithelioma. Benign sebaceous epithelioma, additionally termed as sebaceoma is indicative of sebaceous neoplasm exceeding >50% basaloid cell component and demonstrates yellow papules, nodules or plaques predominating on sites of enhanced sebaceous glands. Dermoscopy delineates yellow-tinged, granular articulations with fine, curvilinear capillaries and vascular formations. Sebaceoma incorporates an admixture of undifferentiated basaloid cells and differentiated sebaceous cells. Basaloid cells enunciate a cytoplasmic vacuolation and sebaceous cells are clear and lipid rich. Histological variants of sebaceoma include carcinoid- like, sinusoidal, reticulated, cribriform, rippled and sebaceoma with Verocay body-like features. Immune reactivity to adipophilin, epithelial membrane antigen (EMA), cytokeratin 5(CK5), cytokeratin 6(CK6) and p40 are elucidated. Sebaceoma requires a distinction from basal cell carcinoma with sebaceous differentiation and trichoblastoma with sebaceous differentiation. Surgical resection of the neoplasm with a narrow surgical resection margin is the preferred therapeutic option.