Lineage tracing clarifies the cellular origin of tissue-resident macrophages in the developing heart

Kuo Liu, Hengwei Jin, Muxue Tang, Shaohua Zhang, Xueying Tian, Mingjun Zhang, Ximeng Han, Xiuxiu Liu, Juan Tang, Wenjuan Pu, Yan Li, Lingjuan He, Zhongzhou Yang, K. O. Lui, Bin Zhou
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引用次数: 7

Abstract

Liu et al. reassess the cellular origin of tissue-resident macrophages in the developing heart. By generating new genetic tools, they reveal that cardiac macrophages are mainly derived from the hemogenic endothelium of yolk sac and aorta-gonad-mesonephros but not from the endocardium.
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谱系追踪阐明了发育中的心脏组织内巨噬细胞的细胞起源
Liu等人重新评估了发育中的心脏组织巨噬细胞的细胞来源。通过建立新的遗传工具,他们揭示了心脏巨噬细胞主要来源于卵黄囊和主动脉-性腺-中肾的造血内皮,而不是来自心内膜。
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