The Influence of Statins on Bone Tissue in Ovariectomized Rats

Current Issue Pub Date : 2018-10-31 DOI:10.33140/tapi/00007

Article, Seferos, G. Rallis, Kotsiou

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Abstract

Objectives: Osteoporosis is a silent, progressive, systemic skeletal disease characterized by impaired bone architecture with decreased bone mass density, affecting mainly women. Statins, inhibitors of HMG-CoA-reductase, seem to interfere with bone formation exerting anabolic and anti-resorptive effect. The aim of the present study is to investigate the effect of simvastatin on size parameters and bone density of mandible and femur, in an ovariectomized rat model of osteoporosis. Methods: 50 Wistar female rats were randomized in five groups (n=10). Groups 1, 2,3 were ovariectomized, 4 and 5 serve as controls. Groups 2, 3 and 5 were treated with simvastatin (0.5mg/kg/daily per os). Size parameters of the isolated femur, mandible and uterus, BMD via dual energy X-Ray absorptiometry (DEXA) and serum interleukin-13 (IL-13) were estimated. Results: DEXA results showed significant decrease of BMD in ovariectomized group / controls while statins treatment decreased the severity of BMD lose. The serum IL-13, as osteogenesis index, seems to be positively influenced by statins treatment. Conclusions: Statins treatment seems to restore the decreased femur and mandible parameters and uterus weight in experimental menopause following ovariectomy.

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他汀类药物对去卵巢大鼠骨组织的影响

目的:骨质疏松症是一种沉默的、进行性的全身性骨骼疾病，其特征是骨结构受损，骨密度下降，主要影响女性。他汀类药物，抑制hmg -辅酶a还原酶，似乎干扰骨形成发挥合成代谢和抗吸收作用。本研究旨在探讨辛伐他汀对去卵巢骨质疏松大鼠下颌骨和股骨大小参数和骨密度的影响。方法:Wistar雌性大鼠50只，随机分为5组(n=10)。1、2、3组切除卵巢，4、5组作为对照组。2、3、5组给予辛伐他汀治疗(0.5mg/kg/d / s)。通过双能x线骨密度仪(DEXA)和血清白细胞介素-13(IL-13)测定离体股骨、下颌骨和子宫的大小参数。结果:DEXA结果显示，去卵巢组/对照组骨密度显著降低，而他汀类药物治疗可降低骨密度损失的严重程度。血清IL-13，作为成骨指数，似乎受到他汀类药物治疗的积极影响。结论:他汀类药物治疗可恢复实验性卵巢切除术后绝经患者股骨、下颌骨参数和子宫重量。

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