Skin-like nanostrucutred biosensor system for noninvasive blood glucose monitoring

Abstract

We present a strategy to design and fabricate a skin-like nanostructured biosensor system (SNBS) that is only 3.8μm thick with high glucose measuring sensitivity. The SNBS is fabricated on the silicon wafer with MEMS fabrication process and then “liquid capillary transferred” off the wafer. The SNBS totally conforms to the skin morphology and fully measures the minimal volume of the analytes distributed among the skin ridges and valleys. The nanostructured electrode facilitates high-efficiency electrochemical deposition of the mechanically robust nano-transducer layer. The SNBS owns significant glucose sensitivity (130.4μA/mM) and good linearity (R2 = 0.95) through large linear ranges. It has been successfully applied to non-invasive blood glucose (BG) monitoring in the in vivo clinical tests on human bodies. The measuring results are highly correlated to the glucometer and the venous blood testing results (>0.9). The SNBS can be used for the first time in clinical-grade fully non-invasive continuous glucose monitoring.