D. A. Bergstein, R. Irani, M. F. Irani, Charles DeLisi, M. S. Unlu
{"title":"Resonant cavity imaging biosensor","authors":"D. A. Bergstein, R. Irani, M. F. Irani, Charles DeLisi, M. S. Unlu","doi":"10.1109/LEOS.2005.1548113","DOIUrl":null,"url":null,"abstract":"The resonant cavity imaging biosensor (RCIB) detects binding between target biomolecules in solution and probe biomolecules fixed to a microarray surface. IR light couples resonantly through a 1 cm square cavity constructed from Si/SiO/sub 2/ Bragg mirrors that contains the microarray surface. As the wavelength of the probe beam is swept, an IR camera monitors cavity transmittance at each pixel. The current setup detects 5 nm relief structures etched in the SiO/sub 2/ surface of one of the Bragg mirrors. RCIB improves on existing label-free biosensing techniques by offering the combination of high sensitivity, high throughput, and real-time observation.","PeriodicalId":317707,"journal":{"name":"Proceedings of the Lightwave Technologies in Instrumentation and Measurement Conference, 2004.","volume":"13 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2005-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Proceedings of the Lightwave Technologies in Instrumentation and Measurement Conference, 2004.","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1109/LEOS.2005.1548113","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
The resonant cavity imaging biosensor (RCIB) detects binding between target biomolecules in solution and probe biomolecules fixed to a microarray surface. IR light couples resonantly through a 1 cm square cavity constructed from Si/SiO/sub 2/ Bragg mirrors that contains the microarray surface. As the wavelength of the probe beam is swept, an IR camera monitors cavity transmittance at each pixel. The current setup detects 5 nm relief structures etched in the SiO/sub 2/ surface of one of the Bragg mirrors. RCIB improves on existing label-free biosensing techniques by offering the combination of high sensitivity, high throughput, and real-time observation.
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