Exposure to Toxic Environmental Agents in the Form of Fragrances and Development of Autism Spectrum Disorders (ASD)

O. Bagasra, A. Bagasra
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引用次数: 1

Abstract

In this chapter, the authors explore how the human brain develops and what the critical stages are in which a fetal brain may acquire genetic and developmental abnormalities through environmental agents. They summarize the prevailing theories regarding the etiologies of autism and present scientific data supporting the thesis that some of the most commonly used environmental agents that we have so easily accepted into our social fabric of life may be major contributors in the development of autism spectrum disorders (ASD). They provide a large body of scientific data carried out in their laboratory, utilizing developing human neurons exposed to femtomolar concentrations of chemicals found in fragrances. The studies demonstrate that synthetic fragrances can impart profound neuromodifications at the morphologic, immunologic, and molecular levels. It is hypothesized that high exposure to teratogenic neurotoxins in our environment during critical periods of development best explains the rapid rise of autism spectrum disorder diagnosis over the past three decades.
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暴露于香水形式的有毒环境物质与自闭症谱系障碍(ASD)的发展
在本章中,作者探讨了人类大脑是如何发育的,以及胎儿大脑可能通过环境因素获得遗传和发育异常的关键阶段是什么。他们总结了关于自闭症病因的主流理论,并提供了支持这一论点的科学数据,即一些我们很容易接受的最常用的环境因素可能是自闭症谱系障碍(ASD)发展的主要因素。他们提供了大量在实验室进行的科学数据,利用暴露于香水中发现的飞摩尔浓度化学物质的发育中的人类神经元。研究表明,合成香料可以在形态学、免疫学和分子水平上给神经系统带来深刻的改变。据推测,在发育的关键时期,我们的环境中高度暴露于致畸神经毒素中,这最好地解释了过去三十年来自闭症谱系障碍诊断的迅速上升。
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