Application of a new electrometric approach to study interaction between biological molecules

N. Starodub, Igor P. Goraychuk, V. M. Starodub, V. V. Il’chenko, G. V. Kuznetsov
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引用次数: 2

Abstract

In the paper the results about changes of the current- voltage characteristics of the surface-barrier structures (SBS) after the deposition of myoglobin and its specific monoclonal antibodies are presented. It was shown that the SBS structures with ultra-thin films or with ultra-thin layer of the porous silicon are sensitive to the presence of the protein or its specific immune complex on their surfaces. The response of the system depended on the conditions of the specific complex formation. The characteristic optimum of the thickness of Ni film or the layer of the porous silicon was revealed when the changes of the I-V characteristics had a maximum level.
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一种新的电测量方法在生物分子间相互作用研究中的应用
本文报道了肌红蛋白及其特异性单克隆抗体沉积后表面屏障结构(SBS)电流电压特性的变化。结果表明,具有超薄薄膜或具有超薄多孔硅层的SBS结构对其表面存在的蛋白质或其特异性免疫复合物敏感。系统的响应取决于特定复杂地层的条件。当I-V特性变化达到最大水平时,呈现出Ni膜厚度或多孔硅层厚度的最优特性。
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