{"title":"Relationship of fibrinolysis system proteins with severity of COVID-19. A review of current clinical data and promising therapeutic strategies","authors":"L. Nekrasova, O. Nesterova, L. Samokhodskaya, E. Semina, A. Kamalov","doi":"10.17116/cardiobulletin20221703129","DOIUrl":null,"url":null,"abstract":"Modern clinical studies show the association of fibrinolysis system factors with complications following COVID-19. This review includes the studies describing the relationship of urokinase plasminogen activator proteins uPA and its receptor uPAR, plasmin-ogen activator inhibitor PAI-1 and plasmin itself with severity of COVID-19. Potential of diagnosis based on analysis of concen-trations and activities of these proteins, as well as expression of their encoding genes is described. These data can predict severe course and possible complications of COVID-19 including thrombosis, respiratory failure and cytokine storm. © 2022, Media Sphera Publishing Group. All rights reserved.","PeriodicalId":305396,"journal":{"name":"Kardiologicheskii vestnik","volume":"76 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Kardiologicheskii vestnik","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.17116/cardiobulletin20221703129","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
纤溶系统蛋白与COVID-19严重程度的关系。回顾当前的临床数据和有希望的治疗策略
现代临床研究表明，纤溶系统因子与COVID-19并发症有关。现就尿激酶纤溶酶原激活物蛋白uPA及其受体uPAR、纤溶酶原激活物抑制剂PAI-1和纤溶酶本身与COVID-19严重程度的关系进行综述。基于分析这些蛋白的浓度和活性，以及它们的编码基因的表达，诊断的潜力被描述。这些数据可以预测COVID-19的严重病程和可能的并发症，包括血栓形成、呼吸衰竭和细胞因子风暴。©2022,Media Sphera出版集团。版权所有。
本文章由计算机程序翻译，如有差异，请以英文原文为准。
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