The Innovative Theory about Autophagic Threshold and (Non)Autophagic Zones

Abstract

The term “autophagic threshold” was mentioned in scientific literature, however more precise explanation is not provided, so the aim of this study is to define this extremely important issue and surrounding autophagic zones. The autophagic threshold is defined as a „turning point“ at which eukaryotic cells begin to generate energy (to maintain their own structure and vital activity) by using (recycling) their internal components. Autophagic thresh-old divides the non-autophagic zone and autophagic zone reflecting the moving to autophagy. Entry into the non-autophagic zone starts when the fasting is interrupted (without fasting never, usually), while to enter the autophagic zone a longer absence of food intake is necessary. The organism in autophagy (by self-eating) sacrifices part of the system in order to restore and maintain the stability of the whole (homeostasis). By eating too often, man disrupts an evolutionarily conserved rhythm and inhibits natural balance leading to the: accumulation of biological waste, working capacity reduction and accelerated aging. Autophagy is therefore a desirable process for every organism, and determining its threshold would mean controlling that process and not wasting time (effectiveness without abstinence). However, the position of the Autophagic Threshold cannot be located in the time, but it can be stimulated, accelerated and intensified using by Fasting, regular physical exercise, ketogenic diet and healthy sleep patterns. Applying any of these methods will bring certain benefits, however, adequate application of all four methods (simultaneously) should be the most powerful way to achieve Autophagic Threshold and thus to achieve healthy longevity and well-being.