Association between FVL G1691A, MTHFR C677T and A1298C Polymorphisms with Risk for Retinopathy of PrematurityAssociation between FVL G1691A, MTHFR C677T and A1298C Polymorphisms with Risk for Retinopathy of Prematurity

World Journal of Peri & Neonatology Pub Date : 2021-10-19 DOI:10.18502/wjpn.v4i1.7540

H. Shajari, M. Ghadyani, Seyed Hamed Hosseini-Jangjou, R. Bahrami, S. A. Dastgheib, H. Neamatzadeh

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Abstract

Background: Retinopathy of prematurity (ROP) is an important cause of preventable blindness in children. The aim of this study was to examine the association of the polymorphisms at Factor V Leiden (FVL) and methylene tetrahydrofolate reductase (MTHFR) gene with risk of ROP. Methods: A total of 106 neonates with ROP and 110 healthy neonates were enrolled. The FVL G1691A and MTHFR C677T and A1298C polymorphisms were genotyped by PCR-RFLP assay. Results: There was a significant association between FVL G1691A polymorphism and an increased risk of ROP. However, the MTHFR C677T and A1298C polymorphisms were not associated with risk of ROP. Conclusion: FVL G1691A polymorphism may be risk factor for development of ROP in neonates. However, there was no significant association between MTHFR C677T and A1298C polymorphisms and risk of ROP. However, it is critical that larger and well-designed studies in different ethnicities are needed to confirm our conclusions.

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FVL G1691A、MTHFR C677T和A1298C多态性与早产儿视网膜病变风险的相关性研究

背景:早产儿视网膜病变(ROP)是儿童可预防性失明的重要原因。本研究的目的是研究因子V Leiden (FVL)和亚甲基四氢叶酸还原酶(MTHFR)基因多态性与ROP风险的关系。方法:选取106例ROP新生儿和110例健康新生儿为研究对象。采用PCR-RFLP方法对FVL G1691A、MTHFR C677T和A1298C基因多态性进行分型。结果:FVL G1691A多态性与ROP风险增加有显著相关性。然而，MTHFR C677T和A1298C多态性与ROP风险无关。结论:FVL G1691A多态性可能是新生儿ROP发生的危险因素。然而，MTHFR C677T和A1298C多态性与ROP风险之间没有显著相关性。然而，重要的是需要在不同种族中进行更大规模和精心设计的研究来证实我们的结论。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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World Journal of Peri & Neonatology

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