H. Shajari, M. Ghadyani, Seyed Hamed Hosseini-Jangjou, R. Bahrami, S. A. Dastgheib, H. Neamatzadeh
Background: Retinopathy of prematurity (ROP) is an important cause of preventable blindness in children. The aim of this study was to examine the association of the polymorphisms at Factor V Leiden (FVL) and methylene tetrahydrofolate reductase (MTHFR) gene with risk of ROP. Methods: A total of 106 neonates with ROP and 110 healthy neonates were enrolled. The FVL G1691A and MTHFR C677T and A1298C polymorphisms were genotyped by PCR-RFLP assay. Results: There was a significant association between FVL G1691A polymorphism and an increased risk of ROP. However, the MTHFR C677T and A1298C polymorphisms were not associated with risk of ROP. Conclusion: FVL G1691A polymorphism may be risk factor for development of ROP in neonates. However, there was no significant association between MTHFR C677T and A1298C polymorphisms and risk of ROP. However, it is critical that larger and well-designed studies in different ethnicities are needed to confirm our conclusions.
{"title":"Association between FVL G1691A, MTHFR C677T and A1298C Polymorphisms with Risk for Retinopathy of PrematurityAssociation between FVL G1691A, MTHFR C677T and A1298C Polymorphisms with Risk for Retinopathy of Prematurity","authors":"H. Shajari, M. Ghadyani, Seyed Hamed Hosseini-Jangjou, R. Bahrami, S. A. Dastgheib, H. Neamatzadeh","doi":"10.18502/wjpn.v4i1.7540","DOIUrl":"https://doi.org/10.18502/wjpn.v4i1.7540","url":null,"abstract":"Background: Retinopathy of prematurity (ROP) is an important cause of preventable blindness in children. The aim of this study was to examine the association of the polymorphisms at Factor V Leiden (FVL) and methylene tetrahydrofolate reductase (MTHFR) gene with risk of ROP. \u0000Methods: A total of 106 neonates with ROP and 110 healthy neonates were enrolled. The FVL G1691A and MTHFR C677T and A1298C polymorphisms were genotyped by PCR-RFLP assay. \u0000Results: There was a significant association between FVL G1691A polymorphism and an increased risk of ROP. However, the MTHFR C677T and A1298C polymorphisms were not associated with risk of ROP. \u0000Conclusion: FVL G1691A polymorphism may be risk factor for development of ROP in neonates. However, there was no significant association between MTHFR C677T and A1298C polymorphisms and risk of ROP. However, it is critical that larger and well-designed studies in different ethnicities are needed to confirm our conclusions.","PeriodicalId":328568,"journal":{"name":"World Journal of Peri & Neonatology","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124630820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Life-threatening intracardiac thrombosis is rare. Intracardiac thrombosis may affect neonates from the first months of life. Because of the potential risk of serious bleeding, the use of recombinant plasminogen activator (rt-PA) in neonates along with heparin is controversial. Case Report: We reported a 37- day- old term infant presented with fever, restlessness, malaise, and respiratory acidosis. Right atrial thrombose was identified by ECHO, results of laboratory tests, and examination. She was successfully treated with rt-PA and rivaroxaban. Conclusion: Early echocardiographic detection before the clot grows large and organized, allows complete, safe, and rapid thrombolysis with rt-PA and rivaroxaban.
{"title":"Intracardiac Thrombosis in A Neonate: A Case Report","authors":"S. R. Mirjalili, M. Danaeian, Fatemeh Baghalsafa","doi":"10.18502/wjpn.v4i1.7547","DOIUrl":"https://doi.org/10.18502/wjpn.v4i1.7547","url":null,"abstract":"Background: Life-threatening intracardiac thrombosis is rare. Intracardiac thrombosis may affect neonates from the first months of life. Because of the potential risk of serious bleeding, the use of recombinant plasminogen activator (rt-PA) in neonates along with heparin is controversial. \u0000Case Report: We reported a 37- day- old term infant presented with fever, restlessness, malaise, and respiratory acidosis. Right atrial thrombose was identified by ECHO, results of laboratory tests, and examination. She was successfully treated with rt-PA and rivaroxaban. \u0000Conclusion: Early echocardiographic detection before the clot grows large and organized, allows complete, safe, and rapid thrombolysis with rt-PA and rivaroxaban.","PeriodicalId":328568,"journal":{"name":"World Journal of Peri & Neonatology","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114962600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fatemeh Baghalsafa, H. Neamatzadeh, Sedigheh Ekraminasab
Background: Several numbers of studies have reported that coronavirus disease-2019 (COVID-19) in infants and children have shown milder symptoms and a better prognosis than in adult patients. However, there is no sufficient evidence on the effect of cardiovascular involvement in COVID-19 in the infant. Case Report: Here, we report an infant infected with COVID-19 with the manifestations of dilated myocarditis. The patient was referred to Pediatric Emergency with lethargy and tachypnea. On physical examination, she had holosystolic murmur with grade 3/6. The laboratory examinations showed anemia as well as increased alkaline phosphatase (ALP) levels. Due to respiratory distress, she was intubated and put under mechanical ventilation. The diagnosis of COVID-19 infection was confirmed by real-time polymerase chain reaction (RT-PCR) using a pharyngeal specimen. Finally, dilated cardiomyopathy (DCM) was diagnosed and one day after hospitalization the infant was died due to complications of DCM. Conclusion: It seems that in the infant with severe underlying disease, even a mild COVID-19 infection, may be lethal. Focal viral myocarditis is a very rare condition described by localized disturbance of the myocardium occurring in ventricular dysfunction with significant morbidity and mortality. Thus, due to the possibility of cardiac injury in infected neonates with COVID-19 disease and the manifestation of myocarditis, effective measurement is recommended.
{"title":"Death of a 3 Month-Old Infected Infant with Dilated Cardiomyopathy after COVID-19 Infection: A Case Report","authors":"Fatemeh Baghalsafa, H. Neamatzadeh, Sedigheh Ekraminasab","doi":"10.18502/wjpn.v4i1.7546","DOIUrl":"https://doi.org/10.18502/wjpn.v4i1.7546","url":null,"abstract":"Background: Several numbers of studies have reported that coronavirus disease-2019 (COVID-19) in infants and children have shown milder symptoms and a better prognosis than in adult patients. However, there is no sufficient evidence on the effect of cardiovascular involvement in COVID-19 in the infant. \u0000Case Report: Here, we report an infant infected with COVID-19 with the manifestations of dilated myocarditis. The patient was referred to Pediatric Emergency with lethargy and tachypnea. On physical examination, she had holosystolic murmur with grade 3/6. The laboratory examinations showed anemia as well as increased alkaline phosphatase (ALP) levels. Due to respiratory distress, she was intubated and put under mechanical ventilation. The diagnosis of COVID-19 infection was confirmed by real-time polymerase chain reaction (RT-PCR) using a pharyngeal specimen. Finally, dilated cardiomyopathy (DCM) was diagnosed and one day after hospitalization the infant was died due to complications of DCM. \u0000Conclusion: It seems that in the infant with severe underlying disease, even a mild COVID-19 infection, may be lethal. Focal viral myocarditis is a very rare condition described by localized disturbance of the myocardium occurring in ventricular dysfunction with significant morbidity and mortality. Thus, due to the possibility of cardiac injury in infected neonates with COVID-19 disease and the manifestation of myocarditis, effective measurement is recommended.","PeriodicalId":328568,"journal":{"name":"World Journal of Peri & Neonatology","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134100641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H. Neamatzadeh, M. Zare-Shehneh, M. Mazaheri, K. Daliri, E. Akbarian, E. Sheikhpour
Background: The previous published data on the association between interferon regulatory factor 6 (IRF6) polymorphisms and non-syndromic Cleft Lip/Palate (NSCL ± P) risk remained inconclusive. The aim of this study was to conduct a meta-analysis to further assess the associations. Methods: A comprehensive search in PubMed, EMBASE, Web of Science, and CNKI for all eligible studies up July 2021. Results: A total of 23 studies with 6,161 cases and 8,919 controls were selected for this meta-analysis. Overall pooled analysis suggest a significant association between IRF6 rs2235371 polymorphism and CL±P risk under all the five genetic models, i.e., allele (A vs. G: OR=0.754, 95% CI 0.628-0.905, P=0.002), homozygote (AA vs. GG: OR=0.621 95% 0.405-0.953, P=0.029), heterozygote (AC vs. GG: OR=0.619, 95% CI 0.485-0.791, P≤0.001), dominant (AA+AG vs. GG: OR=0.550, 95% CI 0.381-0.794, P=0.001) and recessive model (AA vs. AG+GG: OR=0.583, 95% CI 0.423-0.804, P=0.001). Subgroup analysis by ethnicity showed that rs2235371 was associated with NSCL±P risk in Asians. Conclusion: This meta-analysis provides strong evidences that IRF6 rs2235371 might be associated with risk of NSCL ± P.
背景:先前发表的关于干扰素调节因子6 (IRF6)多态性与非综合征性唇腭裂(NSCL±P)风险之间关系的数据仍然没有定论。本研究的目的是进行一项荟萃分析，以进一步评估这些关联。方法:综合检索PubMed、EMBASE、Web of Science和CNKI，检索截至2021年7月的所有符合条件的研究。结果:本次荟萃分析共纳入23项研究，6161例病例和8919例对照。综合分析表明，在等位基因(a对G: OR=0.754, 95% CI 0.628 ~ 0.905, P=0.002)、纯合子(AA对GG: OR=0.621, 95% CI 0.405 ~ 0.953, P=0.029)、杂合子(AC对GG: OR=0.619, 95% CI 0.485 ~ 0.791, P≤0.001)、显性(AA+AG对GG: OR=0.550, 95% CI 0.381 ~ 0.794, P=0.001)和隐性模型(AA对AG+GG: OR=0.583, 95% CI 0.423 ~ 0.804, P=0.001)下，IRF6 rs2235371多态性与CL±P风险均存在显著相关性。种族亚组分析显示，rs2235371与亚洲人的NSCL±P风险相关。结论:本荟萃分析提供了强有力的证据，证明IRF6 rs2235371可能与nsl±P的风险相关。
{"title":"Association of IRF6 rs2235371 Polymorphism with Non-Syndromic Cleft Lip/Palate: A Meta-analysis","authors":"H. Neamatzadeh, M. Zare-Shehneh, M. Mazaheri, K. Daliri, E. Akbarian, E. Sheikhpour","doi":"10.18502/wjpn.v4i1.7541","DOIUrl":"https://doi.org/10.18502/wjpn.v4i1.7541","url":null,"abstract":"Background: The previous published data on the association between interferon regulatory factor 6 (IRF6) polymorphisms and non-syndromic Cleft Lip/Palate (NSCL ± P) risk remained inconclusive. The aim of this study was to conduct a meta-analysis to further assess the associations. \u0000Methods: A comprehensive search in PubMed, EMBASE, Web of Science, and CNKI for all eligible studies up July 2021. \u0000Results: A total of 23 studies with 6,161 cases and 8,919 controls were selected for this meta-analysis. Overall pooled analysis suggest a significant association between IRF6 rs2235371 polymorphism and CL±P risk under all the five genetic models, i.e., allele (A vs. G: OR=0.754, 95% CI 0.628-0.905, P=0.002), homozygote (AA vs. GG: OR=0.621 95% 0.405-0.953, P=0.029), heterozygote (AC vs. GG: OR=0.619, 95% CI 0.485-0.791, P≤0.001), dominant (AA+AG vs. GG: OR=0.550, 95% CI 0.381-0.794, P=0.001) and recessive model (AA vs. AG+GG: OR=0.583, 95% CI 0.423-0.804, P=0.001). Subgroup analysis by ethnicity showed that rs2235371 was associated with NSCL±P risk in Asians. \u0000Conclusion: This meta-analysis provides strong evidences that IRF6 rs2235371 might be associated with risk of NSCL ± P.","PeriodicalId":328568,"journal":{"name":"World Journal of Peri & Neonatology","volume":"531 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124511117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Congenital heart disease (CHD) may have serious effects on the course of COVID-19. Limited data were available on CHD in neonates with COVID-19. This study aimed to review the cardiac complications in neonates infected with COVID-19. Some studies showed that myocardial injury in adult patients is often correlated with a fatal outcome. But, scientific evidence in infants is rare, although several reports were published with the description of cardiac involvement in COVID-19 pediatric patients. In these young subjects, a background of surgically treated CHD seems to be a predisposing factor. Numerous studies showed Multisystem inflammatory syndrome in children (MIS-c) is a deadly demonstration of COVID-19 with cardiac involvement. The underlying pathophysiology of COVID-19-associated cardiovascular complications is not fully understood, although direct viral infection of the myocardium, systemic inflammatory response, coagulation abnormalities and thrombosis and hypoxia have been suggested as possible mechanisms of cardiac complications. It seems COVID-19 can affect different parts of the heart; however, the myocardium is more involved. The mechanisms of pathogenesis of cardiovascular implications in adults and infants are similar but CHD and MIS-c in infants are more important. Further studies on the effects of COVID-19 on the neonatal cardiovascular system are needed.
{"title":"A Survey on Cardiac Complications of COVID-19 in Infants","authors":"R. Bahrami, Sedigheh Ekraminasab, F. Asadian","doi":"10.18502/wjpn.v4i1.7544","DOIUrl":"https://doi.org/10.18502/wjpn.v4i1.7544","url":null,"abstract":"Congenital heart disease (CHD) may have serious effects on the course of COVID-19. Limited data were available on CHD in neonates with COVID-19. This study aimed to review the cardiac complications in neonates infected with COVID-19. Some studies showed that myocardial injury in adult patients is often correlated with a fatal outcome. But, scientific evidence in infants is rare, although several reports were published with the description of cardiac involvement in COVID-19 pediatric patients. In these young subjects, a background of surgically treated CHD seems to be a predisposing factor. Numerous studies showed Multisystem inflammatory syndrome in children (MIS-c) is a deadly demonstration of COVID-19 with cardiac involvement. The underlying pathophysiology of COVID-19-associated cardiovascular complications is not fully understood, although direct viral infection of the myocardium, systemic inflammatory response, coagulation abnormalities and thrombosis and hypoxia have been suggested as possible mechanisms of cardiac complications. It seems COVID-19 can affect different parts of the heart; however, the myocardium is more involved. The mechanisms of pathogenesis of cardiovascular implications in adults and infants are similar but CHD and MIS-c in infants are more important. Further studies on the effects of COVID-19 on the neonatal cardiovascular system are needed.","PeriodicalId":328568,"journal":{"name":"World Journal of Peri & Neonatology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114671015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Anxiety, depression, and stress during the pregnancy period are usually overlooked in women despite their detrimental effects on the mother and infant. Studies have shown an increase in the risk of behavioral and psychological problems in an infant's life because of the mother's exposure to negative excitement and stress before childbirth. In the present study, we aimed to assess the effect of maternal anxiety, depression, and stress during pregnancy on neonatal growth indices at birth. Methods: This longitudinal survey was done on 102 pregnant women referred to the obstetrics clinic of Shahid Sadoughi Hospital of Yazd for prenatal care from September 2019 to March 2020. They were asked to fulfill two questionnaires related to the study. After delivery, the further information and growth indices of neonates were extracted by telephone. Results: Regardless of the severity of depression, anxiety, and stress, a significant relationship was found between maternal age and stress (P= 0.033), so in mothers with younger age, pregnancy stress was more. Moreover, the study showed a significant relationship between height and maternal anxiety (P = 0.018). Conclusion: Based on the findings of this study and due to the possible association of neonatal indices with maternal anxiety, depression, and stress during pregnancy, more attention to maternal emotional health seems necessary.
{"title":"Maternal Anxiety, Depression, and Stress during Pregnancy and Neonatal Growth Indices at Birth","authors":"Zahra Nafei, Elahe Zare, Tahereh Sadeghieh","doi":"10.18502/wjpn.v4i1.7539","DOIUrl":"https://doi.org/10.18502/wjpn.v4i1.7539","url":null,"abstract":"Background: Anxiety, depression, and stress during the pregnancy period are usually overlooked in women despite their detrimental effects on the mother and infant. Studies have shown an increase in the risk of behavioral and psychological problems in an infant's life because of the mother's exposure to negative excitement and stress before childbirth. In the present study, we aimed to assess the effect of maternal anxiety, depression, and stress during pregnancy on neonatal growth indices at birth. \u0000Methods: This longitudinal survey was done on 102 pregnant women referred to the obstetrics clinic of Shahid Sadoughi Hospital of Yazd for prenatal care from September 2019 to March 2020. They were asked to fulfill two questionnaires related to the study. After delivery, the further information and growth indices of neonates were extracted by telephone. \u0000Results: Regardless of the severity of depression, anxiety, and stress, a significant relationship was found between maternal age and stress (P= 0.033), so in mothers with younger age, pregnancy stress was more. Moreover, the study showed a significant relationship between height and maternal anxiety (P = 0.018). \u0000Conclusion: Based on the findings of this study and due to the possible association of neonatal indices with maternal anxiety, depression, and stress during pregnancy, more attention to maternal emotional health seems necessary.","PeriodicalId":328568,"journal":{"name":"World Journal of Peri & Neonatology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131267597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Karimi-Zarchi, D. Schwartz, S. A. Dastgheib, R. Bahrami, A. Javaheri, A. Emarati, F. Asadian, E. Akbarian, H. Neamatzadeh
Background: The aim of this meta-analysis was to estimate the prevalence of cesarean section (CS), preterm birth, stillbirth, and low birth weight deliveries (LBWD) in pregnant women with SARS-COV-2 infection. Methods: All relevant studies were searched up to 30 February 2021. Results: A total of 47 studies with 5970 infected pregnant women were included. There were 1010 CS, 55 stillbirths, 524 preterm birth, and 82 with LBWD. Pooled data showed that the prevalence of CS, preterm birth, stillbirth, and LBWD among women with SARS-COV-2 infection was 29.6% (95% CI 0.081-0.160), 2.1% (95% CI 0.081-0.160), 11.5% (95% CI 0.081-0.160), and 2.1% (95% CI 0.081-0.160), respectively. Stratified analysis revealed that these pregnancy outcomes among Asian women were higher than Caucasians. Conclusion: Our combined data revealed that the CS prevalence (29.6%) was the highest followed by preterm birth (11.5%), stillbirth (2.1%), and LBWD (2.1%) among women with COVID-19.
背景:本荟萃分析的目的是估计感染SARS-COV-2的孕妇剖宫产(CS)、早产、死产和低出生体重分娩(LBWD)的患病率。方法:检索截至2021年2月30日的所有相关研究。结果:共纳入47项研究，5970名感染孕妇。CS 1010例，死产55例，早产524例，LBWD 82例。汇总数据显示，感染SARS-COV-2的妇女中CS、早产、死产和LBWD的患病率分别为29.6% (95% CI 0.081-0.160)、2.1% (95% CI 0.081-0.160)、11.5% (95% CI 0.081-0.160)和2.1% (95% CI 0.081-0.160)。分层分析显示，亚洲妇女的这些妊娠结局高于白种人。结论:我们的综合数据显示，在COVID-19女性中，CS患病率最高(29.6%)，其次是早产(11.5%)、死产(2.1%)和LBWD(2.1%)。
{"title":"A Meta-Analysis for Prevalence of Cesarean Section, Preterm Birth, Stillbirth, and Low Birth Weight Deliveries in Infected Pregnant Women with COVID-19","authors":"M. Karimi-Zarchi, D. Schwartz, S. A. Dastgheib, R. Bahrami, A. Javaheri, A. Emarati, F. Asadian, E. Akbarian, H. Neamatzadeh","doi":"10.18502/wjpn.v4i1.7542","DOIUrl":"https://doi.org/10.18502/wjpn.v4i1.7542","url":null,"abstract":"Background: The aim of this meta-analysis was to estimate the prevalence of cesarean section (CS), preterm birth, stillbirth, and low birth weight deliveries (LBWD) in pregnant women with SARS-COV-2 infection. \u0000Methods: All relevant studies were searched up to 30 February 2021. \u0000Results: A total of 47 studies with 5970 infected pregnant women were included. There were 1010 CS, 55 stillbirths, 524 preterm birth, and 82 with LBWD. Pooled data showed that the prevalence of CS, preterm birth, stillbirth, and LBWD among women with SARS-COV-2 infection was 29.6% (95% CI 0.081-0.160), 2.1% (95% CI 0.081-0.160), 11.5% (95% CI 0.081-0.160), and 2.1% (95% CI 0.081-0.160), respectively. Stratified analysis revealed that these pregnancy outcomes among Asian women were higher than Caucasians. \u0000Conclusion: Our combined data revealed that the CS prevalence (29.6%) was the highest followed by preterm birth (11.5%), stillbirth (2.1%), and LBWD (2.1%) among women with COVID-19.","PeriodicalId":328568,"journal":{"name":"World Journal of Peri & Neonatology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128765972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Jaundice is the most common clinical problem among newborns. It could be caused by different factors, including infections such as urinary tract infection (UTI). We investigated the prevalence of UTI in Iranian newborns with jaundice and prolonged jaundice in this study based on a larger sample of existing data. Methods: We searched the databases of PubMed, Web of Sciences, Scopus, CNKI, SciELO, and Google Scholar for English articles, and a search was also done in Persian in Magiran and Scientific Information Database (SID) published until July 2021. Data analysis was performed by Comprehensive Meta-Analysis (CMA) version 2.0 software. Results: This study included 19 eligible articles out of approximately 240 retrieved articles. The prevalence of UTIs in neonates with jaundice was estimated by pooling the data from 7416 neonates with jaundice. Of those, 369 cases had UTI. Combined data revealed that the prevalence of UTI in neonates with jaundice was 5.4% (95% CI 0.032-0.089, P ≤ 0.001) and there was no publication bias. Conclusion: The overall prevalence of UTI in Iranian newborns with jaundice was 5.4%. However, more studies with a large sample size are required for better results. Also our review showed a screening of UTI should be considered for infants with jaundice, especially prolonged jaundice.
背景:黄疸是新生儿中最常见的临床问题。它可能由不同的因素引起，包括尿路感染(UTI)等感染。在本研究中，我们基于现有数据的更大样本调查了伊朗新生儿黄疸和长期黄疸中尿路感染的患病率。方法:检索PubMed、Web of Sciences、Scopus、CNKI、SciELO、Google Scholar等数据库的英文文章，并检索截至2021年7月出版的波斯语Magiran和科学信息数据库(SID)。采用综合meta分析(Comprehensive Meta-Analysis, CMA) 2.0版软件进行数据分析。结果:本研究在约240篇检索文章中纳入了19篇符合条件的文章。通过汇总来自7416名黄疸新生儿的数据，估计了黄疸新生儿中尿路感染的患病率。其中，369例患有尿路感染。综合数据显示，新生儿黄疸尿路感染患病率为5.4% (95% CI 0.032-0.089, P≤0.001)，无发表偏倚。结论:伊朗新生儿黄疸尿路感染总体患病率为5.4%。然而，为了获得更好的结果，需要更多的大样本量的研究。此外，我们的回顾显示，对于患有黄疸的婴儿，特别是长期黄疸，应考虑进行尿路感染筛查。
{"title":"Prevalence of Urinary Tract Infection in Iranian Newborns with Jaundice: A Meta-Analysis","authors":"M. Lookzadeh, R. Bahrami, Sedigheh Ekraminasab","doi":"10.18502/wjpn.v4i1.7543","DOIUrl":"https://doi.org/10.18502/wjpn.v4i1.7543","url":null,"abstract":"Background: Jaundice is the most common clinical problem among newborns. It could be caused by different factors, including infections such as urinary tract infection (UTI). We investigated the prevalence of UTI in Iranian newborns with jaundice and prolonged jaundice in this study based on a larger sample of existing data. \u0000Methods: We searched the databases of PubMed, Web of Sciences, Scopus, CNKI, SciELO, and Google Scholar for English articles, and a search was also done in Persian in Magiran and Scientific Information Database (SID) published until July 2021. Data analysis was performed by Comprehensive Meta-Analysis (CMA) version 2.0 software. \u0000Results: This study included 19 eligible articles out of approximately 240 retrieved articles. The prevalence of UTIs in neonates with jaundice was estimated by pooling the data from 7416 neonates with jaundice. Of those, 369 cases had UTI. Combined data revealed that the prevalence of UTI in neonates with jaundice was 5.4% (95% CI 0.032-0.089, P ≤ 0.001) and there was no publication bias. \u0000Conclusion: The overall prevalence of UTI in Iranian newborns with jaundice was 5.4%. However, more studies with a large sample size are required for better results. Also our review showed a screening of UTI should be considered for infants with jaundice, especially prolonged jaundice.","PeriodicalId":328568,"journal":{"name":"World Journal of Peri & Neonatology","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129623585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Razieh Alivand, F. Abdi, Mahmood Dehghani-Ashkezari, H. Neamatzadeh, Sedigheh Ekraminasab
Background: Recurrent miscarriage (RM) is one of the major problems of public health globally. The thrombin-activatable fibrinolysis inhibitor (TAFI) gene is a plasma zymogen that regulates both fibrinolysis and inflammation. Genetic variants within TAFI gene are presumed to be associated with development of RM. This case-control study aimed to investigate the association of TAFI +505A>G polymorphism with RM in Iranian women referred to Meybod Genetic Center. Methods: Fifty women with RM (at least 2 miscarriages) and 50 healthy women with no history of miscarriage or other fertility complications were participated in this study. The TAFI +505A>G polymorphism was genotyped by allele specific PCR (AS-PCR) assay. Results: The mean age of cases with RM and controls was 27.25 ± 4.31 and 28.42 ± 3.22 years, respectively. The frequency of GG genotype and G allele was 0.00% in patients and controls. There was no significant difference between RM cases and controls in terms of +505A>G genotypes and alleles. Conclusion: This study results indicated that there was no significant relationship between the TAFI +505A>G polymorphism and RM risk in Iranian women. However, further rigorous, studies with a larger sample size and different ethnicity are necessary to confirm our findings.
{"title":"Association of +505A>G Polymorphism at TAFI Gene with Recurrent Miscarriage in Iranian Women","authors":"Razieh Alivand, F. Abdi, Mahmood Dehghani-Ashkezari, H. Neamatzadeh, Sedigheh Ekraminasab","doi":"10.18502/WJPN.V3I2.6156","DOIUrl":"https://doi.org/10.18502/WJPN.V3I2.6156","url":null,"abstract":"Background: Recurrent miscarriage (RM) is one of the major problems of public health globally. The thrombin-activatable fibrinolysis inhibitor (TAFI) gene is a plasma zymogen that regulates both fibrinolysis and inflammation. Genetic variants within TAFI gene are presumed to be associated with development of RM. This case-control study aimed to investigate the association of TAFI +505A>G polymorphism with RM in Iranian women referred to Meybod Genetic Center. \u0000Methods: Fifty women with RM (at least 2 miscarriages) and 50 healthy women with no history of miscarriage or other fertility complications were participated in this study. The TAFI +505A>G polymorphism was genotyped by allele specific PCR (AS-PCR) assay. \u0000Results: The mean age of cases with RM and controls was 27.25 ± 4.31 and 28.42 ± 3.22 years, respectively. The frequency of GG genotype and G allele was 0.00% in patients and controls. There was no significant difference between RM cases and controls in terms of +505A>G genotypes and alleles. \u0000Conclusion: This study results indicated that there was no significant relationship between the TAFI +505A>G polymorphism and RM risk in Iranian women. However, further rigorous, studies with a larger sample size and different ethnicity are necessary to confirm our findings.","PeriodicalId":328568,"journal":{"name":"World Journal of Peri & Neonatology","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130504600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nasim Shirgholami, F. Abdi, M. Mazaheri, Razieh Sadat Tabatabaee
Background: Amniocentesis, like other invasive methods, has complications such as abortion, premature rupture - second pregnancy and at 29 weeks of membranes, infection, bleeding, etc. Here, we aimed to study the complications of amniocentesis in pregnant women. Methods: This descriptive cross-sectional study was included 409 women with positive first and second stage screening or required amniocentesis referred to Baghaeipour Clinic in 2017. Data was collected by a pre-prepared questionnaire. Results: The mean age of the patients and gestational age was 33.49 ± 6.51 years and 17.39 ± 1.36 weeks, respectively. 132 patients (32.2%) had a history of abortion. Regarding the frequency of needle passage through the placenta, the results showed that in 369 people (90.2%) the needle did not pass through the placenta and in 40 people (9.8%). The needle has passed through the pair. Regarding the frequency distribution of amniocentesis complications, fetal death in (2.4%), bleeding in (2.2%) and PROM (1.7%) were observed in patients and no case of infection and abortion was observed. In terms of age, gestational age, gestational number, placental location, needle passage, aspirated fluid color, history of abortion and type of delivery, there were no significant differences. Conclusion: In this study the most common complication of amniocentesis was fetal death (2.4%), followed by bleeding and Spotting (2.2%), PROM (1.7%), infection and abortion, respectively.
{"title":"Amniocentesis Complications in Yazd Baghaeipour Polyclinic: A Cross-Sectional Study","authors":"Nasim Shirgholami, F. Abdi, M. Mazaheri, Razieh Sadat Tabatabaee","doi":"10.18502/WJPN.V3I1.5061","DOIUrl":"https://doi.org/10.18502/WJPN.V3I1.5061","url":null,"abstract":"Background: Amniocentesis, like other invasive methods, has complications such as abortion, premature rupture - second pregnancy and at 29 weeks of membranes, infection, bleeding, etc. Here, we aimed to study the complications of amniocentesis in pregnant women. \u0000Methods: This descriptive cross-sectional study was included 409 women with positive first and second stage screening or required amniocentesis referred to Baghaeipour Clinic in 2017. Data was collected by a pre-prepared questionnaire. \u0000Results: The mean age of the patients and gestational age was 33.49 ± 6.51 years and 17.39 ± 1.36 weeks, respectively. 132 patients (32.2%) had a history of abortion. Regarding the frequency of needle passage through the placenta, the results showed that in 369 people (90.2%) the needle did not pass through the placenta and in 40 people (9.8%). The needle has passed through the pair. Regarding the frequency distribution of amniocentesis complications, fetal death in (2.4%), bleeding in (2.2%) and PROM (1.7%) were observed in patients and no case of infection and abortion was observed. In terms of age, gestational age, gestational number, placental location, needle passage, aspirated fluid color, history of abortion and type of delivery, there were no significant differences. \u0000Conclusion: In this study the most common complication of amniocentesis was fetal death (2.4%), followed by bleeding and Spotting (2.2%), PROM (1.7%), infection and abortion, respectively.","PeriodicalId":328568,"journal":{"name":"World Journal of Peri & Neonatology","volume":"82 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122172177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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