[The mechanisms of the porphyrin conformation of normal blood hemoglobin and in pathology].

G V Maksimov, A A Churin, T N Sokolova, V Z Pashchenko
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Abstract

The spectra of resonance Raman scattering of blood in norm and under pathology (myocardial infarction and sepsis), as well after artificial hemotransfusion or UV photomodification have been studied. It has been shown that under heart pathology the structure of hemoglobin porphyrin macrocycle of erythrocytes changes, the size of porphyrin "nucleus" increases. The opposite conditions are observed at blood sepsis. It has been found that the traditional methods in tissue restoration, hemotransfusion and UV photomodification of blood don't result in complete restoration of hemoporphyrin molecule.

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[正常血红蛋白卟啉构象的机制和病理学]。
研究了正常、病理(心肌梗死和败血症)、人工输血或紫外线照相后血液的共振拉曼散射光谱。在心脏病理下,红细胞血红蛋白卟啉大环结构发生改变,卟啉“核”增大。血脓毒症则相反。传统的组织修复、输血和血液紫外光化等方法均不能完全恢复血卟啉分子。
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