{"title":"[Anti-ulcer effect of the drug OF-743 in an acid model of ulcer formation by the Okabe method].","authors":"T N Iuziuk, G E Samonina, I P Ashmarin","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>The application of acetic acid (100%) on gastric serosa produces hemorrhagic lesions, erosions and ulcers in the gastric mucosa of rats. Intraperitoneal injections of OF-743, a derivative of sydnonimine during 3 days after the acid application have revealed lesser expressed mucosal lesions: only hemorrhagic lesions and rather small erosions. The lesions degree in rats subjected to the action of OF-743 was 2.7 as compared with 4.4 in control rats without OF-743. Our findings indicate that OF-743 shows not only protective antiulcer action, as it was discovered earlier, but has also curative antiulcer effect.</p>","PeriodicalId":18920,"journal":{"name":"Nauchnye doklady vysshei shkoly. Biologicheskie nauki","volume":" 2","pages":"113-7"},"PeriodicalIF":0.0000,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nauchnye doklady vysshei shkoly. Biologicheskie nauki","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
The application of acetic acid (100%) on gastric serosa produces hemorrhagic lesions, erosions and ulcers in the gastric mucosa of rats. Intraperitoneal injections of OF-743, a derivative of sydnonimine during 3 days after the acid application have revealed lesser expressed mucosal lesions: only hemorrhagic lesions and rather small erosions. The lesions degree in rats subjected to the action of OF-743 was 2.7 as compared with 4.4 in control rats without OF-743. Our findings indicate that OF-743 shows not only protective antiulcer action, as it was discovered earlier, but has also curative antiulcer effect.
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