Multifunctional lipopolymeric nanosystem for photothermal assisted cancer therapy

Abstract

PTT has shown promising target cancer therapy and has been able to achieve high cancer cell death rates while rescuing normal tissue. In this article, IR-775 a less explored hydrophobic photosensitizer was used in combination with polyphenols for the treatment of cancer. The nanosystem consists of HSPC, PLA, IR-775 dye and the polyphenols constituents from Terminalia chebula. The lipopolymeric nanosystem HP pIR NPs (HSPC-PLA-polyphenols extract-IR775) exhibit size range of (142.6 ± 2nm). HP pIR NPs have shown excellent intracellular uptake when studied against A549 and zebrafish. Both the PDT/PTT trigger ROS production and enhance the cancer cell death inhibiting the growth of the remnant cell.