Jianping Gao, Saina Li, Lun Zhang, Yang Zhang, Yi Chen, Fangyu Xing, Yingjun Kong, Xi Luo, Guifeng Zhang
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引用次数: 0
Abstract
Titanium alloys coated with collagen have been widely used to improve their biocompatibility. In this study, the titanium alloys were coated with type I collagen (Col I) and type II collagen (Col II), respectively. The coating amount was quantified with HPLC/MS. Their biocompatibility was evaluated and the effects of collagen types on cell differentiation were compared by cellular proteins identification and quantification. The quantity of Col I and Col II coated on titanium alloy were 0.813±0.015 mg and 0.774±0.013 mg, respectively. Mouse Col I and fibronectin were abundantly expressed within Col I group. The most abundant proteins in Col II group were osteopontin and prelamin-A/C. In conclusion, the collagen coating could improve the biocompatibility of titanium alloy materials, and different types of collagen could induce cell to express proteins with various functions.
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