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2021 International Symposium on Biomedical Engineering and Computational Biology最新文献

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The study of variation in the Diagnostic Related Group Weight in a Complex Operative Units of Paediatrics and Paediatric Surgery due to CoViD-19 pandemic CoViD-19大流行对儿科和儿科外科复杂手术单位诊断相关组体重变化的研究
I. Loperto, A. Borrelli, A. Lombardi, M. Triassi
The CoViD-19 pandemic has unfortunately not spared the children. In most cases, the infection is asymptomatic and the serious outcomes are much lower than in adults. Despite this, as the hospital is committed to treating infected patients and limiting the spread of infections, pediatric surgery has also undergone the blocking of procedures deemed deferrable like other surgeries. In light of this, in this study it was decided to analyze how the activity of the Complex Operative Units (COUs) of Pediatrics and Pediatric Surgery in "San Giovanni di Dio and Ruggi d'Aragona" University Hospital of Salerno (Italy) was affected by the pandemic. Both statistical analysis and logistic regression show an increase of patients’ average age and of weight of Diagnostic Related Group (DRG).
不幸的是,CoViD-19大流行未能使儿童幸免。在大多数情况下,感染是无症状的,严重后果远低于成人。尽管如此,由于医院致力于治疗感染患者并限制感染的传播,儿科手术也经历了像其他手术一样被认为可以推迟的手术的阻碍。鉴于此,在本研究中,决定分析萨莱诺大学医院“圣乔瓦尼·迪迪奥和鲁吉·阿拉戈纳”儿科和儿科外科综合手术单元(cou)的活动如何受到大流行的影响。统计分析和logistic回归均显示诊断相关组(DRG)患者的平均年龄和体重增加。
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引用次数: 0
Influence of demographic and organizational factors on the length of hospital stay in a general medicine department: Factors influencing length of stay in general medicine 人口统计学和组织因素对全科住院时间的影响:影响全科住院时间的因素
Martina Profeta, G. Cesarelli, Cristiana Giglio, Giuseppe Ferrucci, A. Borrelli, Francesco Amato
Unnecessary Length of Hospital Stay (LOS) has significant consequences on the economy of the national healthcare system. Numerous factors may influence LOS, such as bad management of resources, beds and surgery procedures. In this work we investigate, among the demographic, clinical and organizational variables, those most affecting the LOS, through the use of Multiple Linear Regression model. Data of 262 patients were collected from the hospital information system of the General Medicine Department of the University L.P-o Hospital “San Giovanni di Dio and Ruggi d'Aragona” of Salerno. The regression model has been tested and optimized by selecting the most appropriate predictors and by finding the best trade-off between the number of independent variables and the absence of multicollinearity in the data. Results show that the variables influencing LOS were the gender, the number of procedures and the discharge modality.
不必要的住院时间(LOS)对国家医疗保健系统的经济产生了重大影响。许多因素可能影响LOS,如资源、床位和手术程序管理不善。在这项工作中,我们通过使用多元线性回归模型,在人口统计学、临床和组织变量中调查那些最影响LOS的变量。262例患者的数据来自萨勒诺大学l.p. -o医院“San Giovanni di Dio and Ruggi d'Aragona”综合内科医院信息系统。通过选择最合适的预测因子,并通过在自变量数量和数据中不存在多重共线性之间找到最佳权衡,对回归模型进行了测试和优化。结果表明,影响LOS的变量为性别、手术次数和出院方式。
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引用次数: 0
Logistic Regression to study the change in length of stay in a department of Ophthalmology in CoViD-19 era Logistic回归分析2019冠状病毒病疫情时期某眼科住院时间的变化
A. Scala, R. Alfano, A. Borrelli, Giovanni Rossi, M. Triassi
The CoViD-19 pandemic since December 2019 has rapidly spread around the world and to date does not seem to stop its run. The world has paid a very high price in terms of human lives lost and economic repercussions. Health systems have generally been severely tested. The strong demand for CoViD-19 patients has resulted in the blocking of deferred elective procedures and a reconversion of beds and human and technological resources towards the management of the pandemic. In this work, the activity of the Department of Ophthalmology in "San Giovanni di Dio and Ruggi d'Aragona" University Hospital of Salerno (Italy) was analyzed. Specifically, the value obtained from a set of data in the year 2019 (pre-pandemic) was compared with that obtained in the following year, in the height of the pandemic. The results show that patients admitted in 2020 have a shorter length of stay.
自2019年12月以来,新冠肺炎大流行在全球迅速蔓延,迄今似乎并未停止蔓延。世界在人命损失和经济影响方面付出了非常高昂的代价。卫生系统普遍受到了严峻考验。对CoViD-19患者的强劲需求导致推迟的选择性手术受阻,病床、人力和技术资源被重新用于大流行的管理。在这项工作中,对意大利萨莱诺大学医院“圣乔瓦尼·迪迪奥和鲁吉·阿拉戈纳”眼科的活动进行了分析。具体而言,将从2019年(大流行前)的一组数据中获得的值与次年(大流行高峰期)获得的值进行比较。结果显示,2020年入院的患者住院时间较短。
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引用次数: 3
Analysis of Personal Dosimetry and Assistance to Patients at a Radiation Therapy Clinic, to Assign Vacation to Exposed Occupational Workers, using Circular Data Analysis 使用循环数据分析分析放射治疗诊所的个人剂量测定和对病人的帮助,为受照射的职业工人分配假期
Erick Estuardo Hernandez, Mansilla Ximena, Omar Chanta
Results of personal dosimetry from occupationally exposed workers were analyzed, as well as the demand for treatments on a radiotherapy clinic. This data was used to determine the optimal time interval to assign vacations to the workers, to optimize patient attention without affecting permissible personal dosimetry of those who work on said vacations. Circular data analysis was used for both samples, to determine the concentration of data on certain months of the year for the corresponding decision making. The results obtained in the present study allow the assignation of vacations for these personnel, optimizing the personal dosimetry during this time and the efficient patient attention.
分析了职业照射工人的个人剂量测定结果,以及对放射治疗诊所的治疗需求。这些数据被用来确定分配休假给工人的最佳时间间隔,以优化病人的注意力,而不影响在假期工作的人允许的个人剂量测定。对这两个样本进行循环数据分析,以确定数据集中在一年中的某些月份,以便做出相应的决策。在本研究中获得的结果允许为这些人员分配假期,优化在此期间的个人剂量测定和有效的患者关注。
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引用次数: 0
Sapindus saponins inhibits tyrosinase & Glutathione-induced melanin deposition by obstructing DOPA and cysteyl derivatives transformation pathways 皂素通过阻断多巴和半胱氨酸衍生物转化途径抑制酪氨酸酶和谷胱甘肽诱导的黑色素沉积
Kang Jin, Yunpeng Sun, Shengxue Zhou
Background/Objective: The ancient Chinese book, the Compendium of Materia Medica, records that the peel of Sapindus whitens and protects the skin. This study focused on the removal of melanin by Sapindus saponins and determining the involvement of TYR & GSH pathways. Methods: The inhibition rate of Sapindus saponins on TYR activity was measured in vitro. SOD, MDA, TYR and GSH levels in mice were measured, and the amount of melanocytes and melanin in the epidermal cells were analyzed microscopically to evaluate the scavenging effect of Sapindus saponins on melanin in vivo. The expression of TYR, TRP-1, and TRP-2 was examined by western blot. Results: Higher inhibition rate (48.69%) was achieved by PIVb and 40% TYR inhibition rate by SA and SB at 1 mg.mL-1. The SOD content could be significantly enhanced and the MDA, TYR and GSH content were decreased by PIVb, SA, and SB. The melanin in PIVb, SA, and SB-treated groups showed a trend of desalination following epidermal cell analysis. In the expression of TYR, TRP-1 and TRP-2, PIVB also played the very important role to reduce the proteins levels. Conclusions: PIVb, SA, and SB in Sapindus saponins exerted effects of melanin clearance and TRY inhibition evidenced by the amount of melanocytes and melanin in the epidermal cells, alleviation of TYR & GSH pathways-mediated melanin deposition, while PIVb had a stronger effect than SA and SB, showing potential as a good candidate for treating melanosis.
背景/目的:中国古籍《本草纲目》中记载,五子果皮具有美白、护肤的作用。本研究主要研究了皂苷对黑色素的去除作用,并确定了TYR和GSH通路的参与。方法:采用体外培养法测定皂角皂苷对TYR活性的抑制率。测定小鼠体内SOD、MDA、TYR和GSH水平,显微镜下观察黑素细胞数量和表皮细胞黑色素含量,评价皂苷对体内黑色素的清除作用。western blot检测TYR、TRP-1、TRP-2的表达。结果:1 mg.mL-1剂量下,PIVb对TYR的抑制率为48.69%,SA和SB对TYR的抑制率为40%。PIVb、SA和SB可显著提高SOD含量,降低MDA、TYR和GSH含量。表皮细胞分析显示,PIVb、SA和SB处理组的黑色素均有淡化的趋势。在TYR、TRP-1和TRP-2的表达中,PIVB也起到了非常重要的降低蛋白水平的作用。结论:皂角皂苷中PIVb、SA、SB具有清除黑色素和抑制TRY的作用,表现在黑色素细胞和表皮细胞中黑色素的增加,减轻TYR和GSH途径介导的黑色素沉积,但PIVb的作用强于SA和SB,可能是治疗黑色素病的良好候选药物。
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引用次数: 0
Use of statistical analysis and logistic regression to study the length of stay in an Emergency Medicine Department in CoViD-19 era 应用统计分析和logistic回归研究新冠肺炎疫情下急诊科住院时间
I. Loperto, Lucia De Coppi, A. Scala, A. Borrelli, Giuseppe Ferrucci, M. Triassi
Since the first case recorded in China in 2019, CoViD-19 has overwhelmed the health systems of all countries. The highly complex request for assistance combined with the fear of contagion have changed the normal activity of hospitals. Conversely, as the pandemic spreads, fewer people are going to the Emergency Department (ED) for non-CoViD diseases. In this study, logistic regression and statistical analysis were used to investigate how the pandemic changed the activity of the Emergency Medicine Department of "San Giovanni di Dio and Ruggi d'Aragona" University Hospital of Salerno (Italy). Patients admitted in 2020 have a higher Length of Stay (LOS) and the mode of discharge is mostly "at home". While the discharge modality 'transferred to another regime in the same hospital' had significantly decreased in order to counter the internal contagion.
自2019年中国出现首例病例以来,新冠肺炎疫情已使各国卫生系统不堪重负。高度复杂的援助请求加上对传染的恐惧改变了医院的正常活动。相反,随着大流行的蔓延,去急诊室看非covid - 19疾病的人越来越少。在这项研究中,采用logistic回归和统计分析来调查大流行如何改变萨莱诺“圣乔瓦尼迪迪奥和鲁吉阿拉戈纳”大学医院(意大利)急诊科的活动。2020年入院患者住院时间(LOS)更高,出院方式以“在家”为主。而出院方式"转移到同一医院的另一制度"已显著减少,以对抗内部传染。
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引用次数: 1
Comparison of machine learning algorithms to predict length of hospital stay in patients undergoing heart bypass surgery 预测心脏搭桥手术患者住院时间的机器学习算法比较
Martina Profeta, A. M. Ponsiglione, C. Ponsiglione, Giuseppe Ferrucci, Cristiana Giglio, A. Borrelli
Patients affected by coronary artery obstruction, generally undergo aortocoronary bypass, an open-heart surgery that considerably affect health care expenditure. Since that, the monitoring and government of Aortocoronary bypass performance may be of help in health care management. In this work we compare various machine learning-based classification algorithms, to determine the length of stay for aortocoronary bypass. Data were collected on a group of 116 patients of the “San Giovanni di Dio e Ruggi D'Aragona” University Hospital of Salerno (Italy). Different socio-demographic, clinical, and organizational factors were taken into consideration as input parameters of the model for carrying out the classification analysis. The predictive capability of each of the tested machine learning algorithms was assessed in terms of accuracy and error percentages in the classification and obtained results were compared. Among the adopted algorithms, the Random Forest showed far better performances than the other ones, with an accuracy level of around 97%, thus potentially suggesting the Random Forest as a reliable predictive tool in the determination of the length of hospital stay of healthcare data for patients undergoing coronary artery bypass surgery.
受冠状动脉阻塞影响的患者通常接受冠状动脉搭桥手术,这是一种对医疗保健支出有很大影响的心内直视手术。因此,对冠状动脉搭桥术的监测和管理可能有助于医疗保健管理。在这项工作中,我们比较了各种基于机器学习的分类算法,以确定冠状动脉旁路手术的住院时间。数据收集了萨勒诺(意大利)“圣乔凡尼·迪迪奥·鲁吉·达阿拉戈纳”大学医院的116名患者。不同的社会人口、临床和组织因素被考虑作为模型的输入参数进行分类分析。根据分类的准确性和错误率评估每种测试的机器学习算法的预测能力,并比较获得的结果。在所采用的算法中,Random Forest的表现远远好于其他算法,准确率在97%左右,这可能表明Random Forest是确定冠状动脉搭桥手术患者医疗数据住院时间的可靠预测工具。
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引用次数: 10
Modeling the variation in length of stay for appendectomy and cholecystectomy interventions in the emergency general surgery 急诊普通外科手术中阑尾切除术和胆囊切除术干预措施住院时间变化的建模
A. M. Ponsiglione, Martina Profeta, Cristiana Giglio, A. Lombardi, A. Borrelli, A. Scala
Emergency general surgery can often represent a challenge in the clinical practice. This is partially due to the annual growth in the overall number of hospital admissions, especially in developed countries, and to the increasing percentage of elderly patients requiring care procedures. In literature, it is known that, when compared to the elective surgical interventions, the procedures in the emergency general surgery are characterized by a significantly higher morbidity and mortality rates and, not least prolonged length of stay (LOS), which constitutes a relevant metric reflecting both the patient satisfaction and the overall quality of the health services. In this paper, we sought to investigate on length of stay (LOS) variation for appendectomy and cholecystectomy interventions in the emergency general surgery by using a multiple regression analysis, with the purpose of identifying those factors that have the highest contribution in increasing the LOS.
急诊普外科在临床实践中往往是一个挑战。这部分是由于住院总人数的年度增长,特别是在发达国家,以及需要护理程序的老年患者百分比的增加。在文献中,众所周知,与选择性手术干预相比,紧急普通外科手术的特点是发病率和死亡率明显更高,尤其是住院时间(LOS)更长,这是反映患者满意度和医疗服务整体质量的相关指标。在本文中,我们试图通过多元回归分析来研究急诊普通外科手术中阑尾切除术和胆囊切除术干预措施的住院时间(LOS)变化,目的是找出那些对LOS增加贡献最大的因素。
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引用次数: 3
Use of regression models to predict glomerular filtration rate in kidney transplanted patients 应用回归模型预测肾移植患者肾小球滤过率
I. Loperto, A. Scala, Lucia Rossano, R. Carrano, S. Federico, M. Triassi, G. Improta
Despite of the numerous progress of modern medicine, organ transplantation is never a free risk procedure. Kidney transplant, in particular, can bring to numerous short and/or long-term problems, like infection or diabetes. Since such problems can appear up to years, a constant monitoring of Kidney transplanted patients is necessary to try and avoid a bad prognosis. Glomerular Filtration rate (GFR) is an important marker to evaluate kidney transplanted patients. Since it is necessary to measure values of GFR over time, new predictive approaches can reveal useful to such scope. In this work we present a Multiple Linear Regression model and a Machine Learning method to correlate GFR with glycaemia (mg/dL) and the dosage of a calcineurin inhibitor. Results show how such model can be useful in a long term evaluation of kidney transplanted patients.
尽管现代医学取得了许多进步,但器官移植从来都不是一个没有风险的手术。尤其是肾脏移植,会带来许多短期和/或长期的问题,比如感染或糖尿病。由于这些问题可能出现长达数年,因此对肾移植患者进行持续监测是必要的,以尽量避免不良预后。肾小球滤过率(Glomerular Filtration rate, GFR)是评价肾移植患者的重要指标。由于有必要测量GFR随时间的值,新的预测方法可以在这种范围内显示有用。在这项工作中,我们提出了一个多元线性回归模型和机器学习方法,将GFR与血糖(mg/dL)和钙调磷酸酶抑制剂的剂量联系起来。结果表明该模型可用于肾移植患者的长期评估。
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引用次数: 2
Extraction and Evaluation of EEG Covariates and Their Influence on GLM Model: EEG covariates and their influence on GLM model 脑电协变量的提取与评价及其对GLM模型的影响:脑电协变量及其对GLM模型的影响
V. Piorecká, F. Černý, M. Piorecký, V. Koudelka, J. Horáček, J. Bušková, M. Brunovský, J. Kopřivová
This study aims at the identification of suitable approaches to dimension reduction methods for EEG covariate extraction for GLM analysis of fMRI time series. We present the results of anatomical and mathematical methods of dimension covariate reduction and their combinations. Individual models according to the used covariates showed that jPCA creates a lower number of significantly correlated voxels. Anatomical reduction balances the number of correlated voxels between mean and jPCA. The choice of covariates has a significant effect on the resulting GLM activations. The average allows generalization to explain a physiological activity, jPCA offers the ability to identify specific activations.
本研究旨在为fMRI时间序列的GLM分析寻找合适的EEG协变量提取降维方法。我们提出了维数协变量降维的解剖和数学方法及其组合的结果。根据所使用的协变量,单个模型显示jPCA创建的显著相关体素数量较少。解剖还原平衡了均值和jPCA之间相关体素的数量。协变量的选择对最终的GLM激活有显著影响。平均允许一般化解释生理活动,jPCA提供了识别特定激活的能力。
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引用次数: 0
期刊
2021 International Symposium on Biomedical Engineering and Computational Biology
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