Factors Influence GLUT-4 Levels of Type 2 Diabetes Mellitus Patients in Medan City, Indonesia

Abstract

The resistance of insulin in type 2 Diabetes mellitus patients (T2DM) will have a significant impact on glucose regulation with Glucose transporter-4 (GLUT-4) translocation. Glucose transporter-4 plays an essential role in the transport of glucose to most cells. The study design was analytic with a cross sectional approach. The study population was T2DM patient in Medan City with the number of people who have fulfilled the inclusion and exclusion criteria amount 83 patients. Data collection is done by interviewing and patient blood test. Assessment of physical activity of diabetic patients using a global questionnaire physical activity (GPAQ). GLUT-4 levels were assessed using Human Glut-4 with ELISA Method. The nutritional status and history of drug use by direct measurement and interviews. Data analysis using independent T-test with SPSS computer program. The results showed there was a relationship between physical activity and obesity with levels of GLUT-4 (p <0.05), and there was no relationship between consumption of drugs with levels of GLUT4 (p <0.05). By increasing physical activity, proper nutrition management and weight control will help improve insulin sensitivity so that it can control blood sugar levels in T2DM patients