Impedance between Micro-Electrodes of a Pair of Concentric Cylinders for Estimation of Local Cell Configuration

Abstract

The micro-electrodes of a pair of concentric cylinders have been designed to estimate the local cell configuration in biological tissues. The micro-electrodes consist with the outer and the inner concentric cylindrical needles of stainless-steel: the diameters of the outer and the inner cylindrical needles are 1.20 mm and 0.60 mm, respectively. The electrodes were inserted into the several types of the normal bovine tissues: the heart, the lever, the kidney, the fatty tissue, or the intestinal mucous membrane, alternatively. The electric voltage between electrodes was measured, while the sinusoidal alternating electric current at the frequency between 1 Hz to 1 MHz flew between the electrodes. The cell density in the tissue was counted at the microscopic image of each tissue. The results show that the capacity component increases with the density of cells. The study demonstrates the designed system of the measurement is effective to estimate the local cell configuration in biological tissues.