New Developments in Behavioral Pharmacology

J. Cueto-Escobedo, F. García-García, C. Maximino, J. Rodríguez-Landa
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Abstract

Behavioral pharmacology research has been a cornerstone in the understanding of the processes that underlie the behavior of living organisms as well as the biological basis of the behavioral, emotional, and cognitive disorders that affect humans. The findings in this area have helped to explore the potential therapeutic effects of several substances for the treatment of the mentioned disorders. The present chapter brings an extremely brief introduction to this vast area. First, we try to put in context behavioral pharmacology and its relevance and then show some brief examples of how this discipline has developed over the years. Second, we review the concept of a “research model” in preclinical behavioral pharmacology, given the importance of animal models and tests in this area, followed by a brief review of the recent advances using zebra fish as a valuable tool of research. Third, more specific examples are aborded, such as the findings on sleep disorders and those related to sexual hormones and menopause. several of on the of a characterized by three phases: adaptation, and exhaustion, can to are maintained. the stress has studied associated with the impairment of brain function in animals the a behavioral tool to explore the of antidepressant drugs in rats
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行为药理学的新进展
行为药理学研究是理解生物体行为背后的过程以及影响人类的行为、情感和认知障碍的生物学基础的基石。这一领域的发现有助于探索几种物质治疗上述疾病的潜在治疗效果。本章对这一广阔领域作了极为简短的介绍。首先,我们试着把行为药理学和它的相关性放在一起,然后展示一些简单的例子来说明这门学科是如何发展的。其次,我们回顾了临床前行为药理学中“研究模型”的概念,考虑到动物模型和实验在该领域的重要性,然后简要回顾了利用斑马鱼作为有价值的研究工具的最新进展。第三,列举了更具体的例子,如睡眠障碍和性激素与更年期相关的研究结果。几个人的一个特点有三个阶段:适应,和疲惫,都能维持下去。研究了应激与动物脑功能损害的关系,为探索抗抑郁药物对大鼠的作用提供了行为学工具
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