Quantitative Study on Biochemical Composition of Knee Joint Based on Magnetic Resonance Physiologic Imaging

Abstract

The emergence of physiological magnetic resonance imaging technology provides a wealth of information for the diagnosis and research of knee cartilage lesions. In this paper, the T2 value of degenerative cartilage in the weight-bearing area of the femoral condyle of knee joint was measured in vitro by using 7.0T magnetic resonance T2 mapping sequence. The water content and collagen content of cartilage in the same site were calculated. The collagen fiber orientation was graded under polarized light microscope, and the T2 value was analyzed. Correlation with water content, collagen content and collagen fiber orientation. The results showed that the T2 value of degenerative weight-bearing cartilage was positively correlated with water content (r=0.70, P=0.000), and had no correlation with collagen content (r=0.14, P=0.200), and was positively correlated with collagen fiber orientation. r = 0.56, P = 0.000). The T2 value of degenerative cartilage in the weight-bearing area of human knee joint was positively correlated with the water content of the extracellular matrix component and the biochemical composition of collagen fiber. The magnetic resonance T2-mapping imaging sequence can accurately reflect under non-invasive conditions. Assessment of cartilage lesions.