{"title":"Nickel Tetrapyrroles in Methanogenic Bacteria: Structure, Function and Biosynthesis","authors":"R.K. Thauer","doi":"10.1016/S0721-9571(82)80039-2","DOIUrl":null,"url":null,"abstract":"<div><p>Most methanogenic bacteria can grow on H<sub>2</sub> plus CO<sub>2</sub> as sole energy source; CO<sub>2</sub> is reduced to methane: 4 H<sub>2</sub> + CO<sub>2</sub> → CH<sub>4</sub> + 4 H<sub>2</sub>O. The exergonic step in this process is probably the reduction of methyl CoM to methane. This reaction is catalyzed by the methyl CoM reductase, the prosthetic group of which is factor F<sub>430</sub>. This factor contains nickel and has been shown to have a nickel tetrapyrrole structure. The involvement of a nickel tetrapyrrole in methane formation explains why growth of all methanogens is dependent on nickel.</p></div>","PeriodicalId":101290,"journal":{"name":"Zentralblatt für Bakteriologie Mikrobiologie und Hygiene: I. Abt. Originale C: Allgemeine, angewandte und ?kologische Mikrobiologie","volume":"3 2","pages":"Pages 265-270"},"PeriodicalIF":0.0000,"publicationDate":"1982-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0721-9571(82)80039-2","citationCount":"15","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Zentralblatt für Bakteriologie Mikrobiologie und Hygiene: I. Abt. Originale C: Allgemeine, angewandte und ?kologische Mikrobiologie","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0721957182800392","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 15
Abstract
Most methanogenic bacteria can grow on H2 plus CO2 as sole energy source; CO2 is reduced to methane: 4 H2 + CO2 → CH4 + 4 H2O. The exergonic step in this process is probably the reduction of methyl CoM to methane. This reaction is catalyzed by the methyl CoM reductase, the prosthetic group of which is factor F430. This factor contains nickel and has been shown to have a nickel tetrapyrrole structure. The involvement of a nickel tetrapyrrole in methane formation explains why growth of all methanogens is dependent on nickel.
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