Subakut Tiroiditte Prognoz Öngörülebilir mi?

Ali Saklamaz, Özcan Çi̇ftçi̇
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Abstract

Aim: Subacute thyroiditis (SAT) is a thyroid disease that seriously affects the quality of life for patients caused by acute inflammation of the thyroid gland. Apart from classical acute phase reactants, the values and rates obtained from peripheral blood count (mean platelet volume (MPV), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR)) values are also accepted as practical indicators of systemic inflammation. Our aim in this study is to compare the effects of systemic inflammation markers and the treatments given in the laboratory tests of our patients with a diagnosis of SAT, on the hypothyroid state one year later. Material and Methods: In this study, which was carried out with a retrospective method, 133 patients were included in the study. The medical data of these patients at the time of SAT diagnosis and one year later were analyzed. 37 patients were in the steroid group and 97 patients were in the nonsteroidal anti-inflammatory drug (NSAID) group. Results: The male/female ratio was similar in both groups. Female dominance was observed in both groups in patients diagnosed with SAT. The thyroid tests of the groups, which were hyperthyroid at the beginning and euthyroid one year later, were similar between the groups (p>0.05). Both groups had an increase in acute phase reactants at baseline (erythrocyte sedimentation rate [ESR] and C-reactive protein (CRP) levels) and normalized after treatment. Neutrophil (p0.05) and platelet (p0.05). Conclusion: Inflammation markers and treatments applied in SAT patients did not have a significant effect on the prognosis
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目的:亚急性甲状腺炎(SAT)是由急性甲状腺炎症引起的严重影响患者生活质量的甲状腺疾病。除了经典的急性期反应物外,外周血计数(平均血小板体积(MPV)、中性粒细胞与淋巴细胞比值(NLR)和血小板与淋巴细胞比值(PLR))的值和速率也被接受为全身性炎症的实用指标。在这项研究中,我们的目的是比较系统性炎症标志物和我们诊断为SAT的患者在一年后甲状腺功能减退状态的实验室检查中给予的治疗的影响。材料与方法:本研究采用回顾性方法,共纳入133例患者。分析这些患者在SAT诊断时和一年后的医疗资料。类固醇组37例,非甾体抗炎药组97例。结果:两组患者男女比例相近。两组在诊断为SAT的患者中均存在女性优势。两组患者的甲状腺指标(开始时甲状腺功能亢进,1年后甲状腺功能正常)相似(p>0.05)。两组的急性期反应物(红细胞沉降率[ESR]和c反应蛋白(CRP)水平)均在基线时升高,治疗后恢复正常。中性粒细胞(p0.05)、血小板(p0.05)。结论:炎症标志物及治疗方法对SAT患者预后无显著影响
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