A Comparative Study of Antifatigue Effects of Taurine and Vitamin C on Chronic Fatigue Syndrome

Pharmacology &amp; Pharmacy Pub Date : 1900-01-01 DOI:10.4236/pp.2022.138023

Shin-Hee Kim, Hyunjin Kim, Semi Kim, Ju‐Seop Kang, Y. Koo, Sang Hun Lee, Dong-Hyun Paik

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引用次数: 2

Abstract

Vitamin C and taurine (TR) are well known as active components for fatigue recovery. However, the mechanism of the anti-fatigue effects of vitamin C and TR is still unclear. Our study was designed to evaluate the anti-fatigue activities of vitamin C and TR in an animal test for fatigue and to compare the activities between vitamin C and TR. Materials and Methods: Vitamin C, TR or their combination were orally administrated to mice once daily for 15 days, and then metabolic activities such as blood glucose, triglyceride (TG), lactate, and lactate dehydrogenase (LDH) as well as antioxidant activities such as malondialdehyde (MDA) and superoxide dismutase (SOD) were determined (evaluated) after forced swimming test (FST). Results: Compared with the control group, C100, C200, and T50 showed a tendency to decrease mobility in FST. Moreover, TG (C100, C200, T200), LDH (C200), lactic acid (C100) and MDA (C50, C100, C200) levels were inhibited by vitamin C and TR. Con-clusions: These results suggest that vitamin C and TR have anti-fatigue activities in mice, with vitamin C providing a stronger effect.

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牛磺酸与维生素C对慢性疲劳综合征抗疲劳作用的比较研究

维生素C和牛磺酸(TR)是众所周知的疲劳恢复的活性成分。然而，维生素C和TR抗疲劳作用的机制尚不清楚。本研究旨在通过疲劳动物试验评价维生素C和TR的抗疲劳活性，并比较维生素C和TR的抗疲劳活性。小鼠每日口服维生素C、TR或其联合用药1次，连续15 d，然后在强迫游泳试验(FST)后测定(评估)小鼠血糖、甘油三酯(TG)、乳酸、乳酸脱氢酶(LDH)等代谢活性以及丙二醛(MDA)、超氧化物歧化酶(SOD)等抗氧化活性。结果:与对照组相比，C100、C200和T50在FST中表现出活动能力下降的趋势。维生素C和TR可抑制小鼠TG (C100、C200、T200)、LDH (C200)、乳酸(C100)和MDA (C50、C100、C200)水平。结论:维生素C和TR具有抗疲劳作用，其中维生素C的作用更强。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Pharmacology &amp; Pharmacy

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