miR-24 and its Role as an Oncogene in Cancer

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Abstract

MicroRNAs (miRNAs) regulate the expression of genes involved in numerous cellular processes, including proliferation, metabolism, differentiation and apoptosis. Changes in the expression levels of miRNAs are associated with the development of various diseases, including cancer. Dysregulation of miRNA expression has been demonstrated to have a role in tumorigenesis and it has been revealed that some miRNAs can act either as oncogenes or tumor suppressors in cancer. miRNA-24 has been identified as an oncogene in various types of cancer. This review discusses the function of miRNA-24 as oncogene in gastric cancer, breast cancer, pancreatic cancer, lung cancer and leukemia.
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miR-24及其在癌症中的致癌基因作用
MicroRNAs (miRNAs)调节参与许多细胞过程的基因表达,包括增殖、代谢、分化和凋亡。mirna表达水平的变化与包括癌症在内的各种疾病的发展有关。miRNA表达的失调已被证明在肿瘤发生中起作用,并且已经发现一些miRNA在癌症中既可以作为癌基因也可以作为肿瘤抑制基因。miRNA-24已被确定为多种癌症的致癌基因。现就miRNA-24作为致癌基因在胃癌、乳腺癌、胰腺癌、肺癌和白血病中的作用作一综述。
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