Yeni Tanı Almış Tip 2 Diabetes Mellitus Hastalarında Plazma E Vitamini ve Plazma Nitrit/Nitrat Anyon Düzeylerinin Değerlendirilmesi

Abstract

Aim: Oxidative stress induces the onset of type 2 Diabetes mellitus (T2DM). Both plasma vitamin E (VE) and nitrite/nitrate anion (NOx) levels might be crucial factors to determine diabetes induced endothelial damage through different mechanisms. Therefore, in this study, we aimed to evaluate plasma VE and NOx concentrations of newly diagnosed T2DM patients and to understand whether any correlation exists with the patients’ lipid profiles. Material and Methods: Blood samples were taken when the patients (n=15) and the controls (n=15) first came to our university’s diabetes policlinic for investigation and were used to detect plasma VE and NOx levels. Patients’ files were evaluated to record both the demographic data and biochemical parameters. The data was distributed normally according to Kolmogorov-Smirnov test. Therefore, Student t test was chosen to compare patient and control data and Pearson test was applied for correlation analysis. Results: In newly diagnosed T2DM patients, total cholesterol (TC) and triglyceride levels were found to be significantly elevated (p=0.036, and p