O cloridrato de procaína e o bicarbonato de sódio – uma opção para a resistência microbiana

Abstract

With the increase in bacterial resistance in recent decades, there is an increasing need for the association of drugs with antimicrobial effects in treatments. In this context, the objective of this study was to evaluate in vitro the antimicrobial effect of 0.7% procaine hydrochloride associated or not with 0.023% sodium bicarbonate on Escherichia coli, Proteus mirabilis and Staphylococcus aureus, pathogens commonly present in urinary tract infections of dogs, by broth dilution and disc diffusion methods. It is thus concluded that 0.7% procaine hydrochloride solutions; 0.023% sodium bicarbonate and solution containing 0.7% procaine hydrochloride with 0.023% sodium bicarbonate have antimicrobial effect against Staphylococcus aureus and Proteus mirabilis, and only 0.7% procaine hydrochloride has antimicrobial action against Escherichia coli.