An ontology-driven clustering method for supporting gene expression analysis

Haiying Wang, F. Azuaje, O. Bodenreider
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引用次数: 31

Abstract

The gene ontology (GO) is an important knowledge resource for biologists and bioinformaticians. This paper explores the integration of similarity information derived from GO into clustering-based gene expression analysis. A system that integrates GO annotations, similarity patterns and expression data in yeast is assessed. In comparison with a clustering model based only on expression data correlation, the proposed framework not only produces consistent results, but also it offers alternative, potentially meaningful views of the biological problem under study. Moreover, it provides the basis for developing other automated, knowledge-driven data mining systems in this and related application areas.
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支持基因表达分析的本体驱动聚类方法
基因本体(GO)是生物学家和生物信息学家的重要知识资源。本文探讨了将GO的相似性信息整合到基于聚类的基因表达分析中。评估了一个集成GO注释、相似模式和酵母表达数据的系统。与仅基于表达数据相关性的聚类模型相比,所提出的框架不仅产生一致的结果,而且还为所研究的生物学问题提供了替代的、潜在的有意义的观点。此外,它还为在此及相关应用领域开发其他自动化、知识驱动的数据挖掘系统提供了基础。
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