K. Tadokoro, Katsuhiko Miki, T. Yamasaki, Toshikazu Yamaguchi, K. Tateda, Kensuke Kondo, Nobuki Arai
{"title":"Epidemiological Characteristics of SARS-CoV-2-Positive Samples in Japan: A Retrospective Study","authors":"K. Tadokoro, Katsuhiko Miki, T. Yamasaki, Toshikazu Yamaguchi, K. Tateda, Kensuke Kondo, Nobuki Arai","doi":"10.29011/2638-003x.100098","DOIUrl":null,"url":null,"abstract":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19). In Japan, infections began in January 2020, and the number of infections has continued to increase. Specimens requested by medical institutions were measured for ORF1a/b, N-gene, and S-gene using TaqPath SARS-CoV-2 real-time polymerase chain reaction detection kits in our biomedical laboratory from January to August 2021. The distribution of threshold cycle (Ct) values of positive samples was analyzed separately every 2 months. The Ct values of saliva samples were normally distributed for all genes, except for the May/June S-gene. By contrast, nasopharyngeal swab samples showed a bimodal distribution from January to June, with a shift toward lower median values in July/August. The results suggest that viruses with different properties may be captured in saliva and nasopharyngeal samples.","PeriodicalId":431682,"journal":{"name":"Current trends in Internal Medicine","volume":"146 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2023-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current trends in Internal Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.29011/2638-003x.100098","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19). In Japan, infections began in January 2020, and the number of infections has continued to increase. Specimens requested by medical institutions were measured for ORF1a/b, N-gene, and S-gene using TaqPath SARS-CoV-2 real-time polymerase chain reaction detection kits in our biomedical laboratory from January to August 2021. The distribution of threshold cycle (Ct) values of positive samples was analyzed separately every 2 months. The Ct values of saliva samples were normally distributed for all genes, except for the May/June S-gene. By contrast, nasopharyngeal swab samples showed a bimodal distribution from January to June, with a shift toward lower median values in July/August. The results suggest that viruses with different properties may be captured in saliva and nasopharyngeal samples.
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