Possibilities of Viral Immune Evasion Exemplified by Human Papilloma Virus in HIV-Infected People

Abstract

Immune surveillance is of great significance for development of papillomavirus infections, as it has an impact on the disease course and its transformation into neoplasias. Immune response in infection of HIV patients with human papillomavirus deserves particular attention. Numerous studies suggest modification of immune response by the viruses in monoinfections (human immunodeficiency virus, human papillomavirus) and in combined infections. At present, numerous possible viral evasion mechanisms of innate and adaptive immunity factors are known. Despite a large body of accumulated knowledge on the HIV and papillomavirus infection course, early diagnosis and timely treatment of coinfected patients are hampered, which adversely affects their prognosis. There is still a need for expanding the techniques for early diagnosis of papillomavirus infection in HIV-infected individuals and searching for effective treatment methods.