Hepatitis C Virus and its Relation to Hepatocellular Carcinoma

Mohit Gururani
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Abstract

Hepatocellular carcinoma is the world’s sixth leading cause of death due to its quick progression. It has a poor prognosis and a low survival rate. Though there are several factors leading to malignancy, some of them are not yet fully understood. For example HCV. Hepatitis C virus is known to cause hepatocellular carcinoma and clearing the viral load of HCV from the body using DAAs has helped in improved prognosis and prevention of HCC but there is no concrete evidence to prove the direct carcinogenic effects of HCV in causing HCC. The argument is that HCV does not directly causes HCC but its chronic effects in the liver eventually lead up to HCC.
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丙型肝炎病毒及其与肝细胞癌的关系
肝细胞癌因其快速进展而成为世界第六大死亡原因。预后差,生存率低。虽然有几种导致恶性肿瘤的因素,但其中一些尚未完全了解。例如HCV。已知丙型肝炎病毒可引起肝细胞癌,使用DAAs清除体内的HCV病毒载量有助于改善预后和预防HCC,但没有具体证据证明HCV在引起HCC中的直接致癌作用。有观点认为,HCV并不直接导致HCC,但其在肝脏中的慢性作用最终导致HCC。
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