Pub Date : 2020-12-01DOI: 10.21088/ijgmr.2319.4782.9220.7
Mohit Gururani
Hepatocellular carcinoma is the world’s sixth leading cause of death due to its quick progression. It has a poor prognosis and a low survival rate. Though there are several factors leading to malignancy, some of them are not yet fully understood. For example HCV. Hepatitis C virus is known to cause hepatocellular carcinoma and clearing the viral load of HCV from the body using DAAs has helped in improved prognosis and prevention of HCC but there is no concrete evidence to prove the direct carcinogenic effects of HCV in causing HCC. The argument is that HCV does not directly causes HCC but its chronic effects in the liver eventually lead up to HCC.
{"title":"Hepatitis C Virus and its Relation to Hepatocellular Carcinoma","authors":"Mohit Gururani","doi":"10.21088/ijgmr.2319.4782.9220.7","DOIUrl":"https://doi.org/10.21088/ijgmr.2319.4782.9220.7","url":null,"abstract":"Hepatocellular carcinoma is the world’s sixth leading cause of death due to its quick progression. It has a poor prognosis and a low survival rate. Though there are several factors leading to malignancy, some of them are not yet fully understood. For example HCV. Hepatitis C virus is known to cause hepatocellular carcinoma and clearing the viral load of HCV from the body using DAAs has helped in improved prognosis and prevention of HCC but there is no concrete evidence to prove the direct carcinogenic effects of HCV in causing HCC. The argument is that HCV does not directly causes HCC but its chronic effects in the liver eventually lead up to HCC.","PeriodicalId":113499,"journal":{"name":"Indian Journal of Genetics and Molecular Research","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127572196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-06-01DOI: 10.21088/IJGMR.2319.4782.8219.2
Dehradun Uttarakhand India. Kaulagarh Road, Junumai Deori, Shailendra Kumar
{"title":"Genetic Polymorphism of Mitochondrial Genome D-loop Region in Bhotia and Buxa Population of Uttarakhand","authors":"Dehradun Uttarakhand India. Kaulagarh Road, Junumai Deori, Shailendra Kumar","doi":"10.21088/IJGMR.2319.4782.8219.2","DOIUrl":"https://doi.org/10.21088/IJGMR.2319.4782.8219.2","url":null,"abstract":"","PeriodicalId":113499,"journal":{"name":"Indian Journal of Genetics and Molecular Research","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115047493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.21088/ijgmr.2319.4782.8119.3
Sonali Sundriyal, Sakshi Kumari, R. Bisht, Usha Chand, N. Sharma, S. Nautiyal
{"title":"Characterization of the Infectious Agent (Hepatitis B Virus) and its Clinical Correlations","authors":"Sonali Sundriyal, Sakshi Kumari, R. Bisht, Usha Chand, N. Sharma, S. Nautiyal","doi":"10.21088/ijgmr.2319.4782.8119.3","DOIUrl":"https://doi.org/10.21088/ijgmr.2319.4782.8119.3","url":null,"abstract":"","PeriodicalId":113499,"journal":{"name":"Indian Journal of Genetics and Molecular Research","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122262855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.21088/ijgmr.2319.4782.8219.5
Sunita Chhikara, Sudha Sazwal, R. Chaubey, M. Mahapatra, R. Saxena
{"title":"Successful Treatment of a Chronic-Phase T-315I-Mutated Chronic Myelogenous Leukemia Patient with a Combination of Hydroxyurea and Interferon-Alfa","authors":"Sunita Chhikara, Sudha Sazwal, R. Chaubey, M. Mahapatra, R. Saxena","doi":"10.21088/ijgmr.2319.4782.8219.5","DOIUrl":"https://doi.org/10.21088/ijgmr.2319.4782.8219.5","url":null,"abstract":"","PeriodicalId":113499,"journal":{"name":"Indian Journal of Genetics and Molecular Research","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133965352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.21088/ijgmr.2319.4782.8119.6
Ronak Sheth, K. Sivakumar, B. Kar, Consultant
{"title":"Congenital Cardiac Defects in Trisomy 18: A Case Series","authors":"Ronak Sheth, K. Sivakumar, B. Kar, Consultant","doi":"10.21088/ijgmr.2319.4782.8119.6","DOIUrl":"https://doi.org/10.21088/ijgmr.2319.4782.8119.6","url":null,"abstract":"","PeriodicalId":113499,"journal":{"name":"Indian Journal of Genetics and Molecular Research","volume":"409 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133005397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.21088/ijgmr.2319.4782.8119.5
Geetanjali, Tejpal, Satyan, S. Chauhan, K. Gupta, Divy Pandey
FISH is a technique that measures gene amplification using fluorescently labeled DNA (probe). The sample of breast tumor tissue is prepared for FISH by heating it. This heating process breaks the DNA into two strands; this produces two single strands of DNA and is called denaturing. The labeled probe is added to the denatured DNA mixture. The fluorescently labeled DNA matches certain regions of the denatured DNA and when the matching regions come in contact with each other they stick together. The mixture is washed so any unbound labeled DNA is removed. The washed mixture is viewed using a special microscope that can detect the color emitted by the probe. The probe marks the areas of DNA (genes) that code for the protein of interest, thus the amount of probe bound to the DNA is an indirect indicator of the number of genes present coding for the protein.
{"title":"Fluorescence in-Situ Hybridization (FISH) and its Importance in Bio-Medical Sciences","authors":"Geetanjali, Tejpal, Satyan, S. Chauhan, K. Gupta, Divy Pandey","doi":"10.21088/ijgmr.2319.4782.8119.5","DOIUrl":"https://doi.org/10.21088/ijgmr.2319.4782.8119.5","url":null,"abstract":"FISH is a technique that measures gene amplification using fluorescently labeled DNA (probe). The sample of breast tumor tissue is prepared for FISH by heating it. This heating process breaks the DNA into two strands; this produces two single strands of DNA and is called denaturing. The labeled probe is added to the denatured DNA mixture. The fluorescently labeled DNA matches certain regions of the denatured DNA and when the matching regions come in contact with each other they stick together. The mixture is washed so any unbound labeled DNA is removed. The washed mixture is viewed using a special microscope that can detect the color emitted by the probe. The probe marks the areas of DNA (genes) that code for the protein of interest, thus the amount of probe bound to the DNA is an indirect indicator of the number of genes present coding for the protein.","PeriodicalId":113499,"journal":{"name":"Indian Journal of Genetics and Molecular Research","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124318611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.21088/ijgmr.2319.4782.8119.2
Sakshi Kumari, Usha Chand, R. Bisht, Sonali Sundriyal, N. Sharma, S. Nautiyal
{"title":"Hepatitis C Virus and its Genotypes detection in Serum Specimens: Clinical Relevance for the Management","authors":"Sakshi Kumari, Usha Chand, R. Bisht, Sonali Sundriyal, N. Sharma, S. Nautiyal","doi":"10.21088/ijgmr.2319.4782.8119.2","DOIUrl":"https://doi.org/10.21088/ijgmr.2319.4782.8119.2","url":null,"abstract":"","PeriodicalId":113499,"journal":{"name":"Indian Journal of Genetics and Molecular Research","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127817548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.21088/ijgmr.2319.4782.8119.7
D. R. Mohan
{"title":"Basic Guidelines of Genetic Counseling","authors":"D. R. Mohan","doi":"10.21088/ijgmr.2319.4782.8119.7","DOIUrl":"https://doi.org/10.21088/ijgmr.2319.4782.8119.7","url":null,"abstract":"","PeriodicalId":113499,"journal":{"name":"Indian Journal of Genetics and Molecular Research","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122836463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.21088/ijgmr.2319.4782.8219.3
H. Krishna, S. Dixit
{"title":"Circulating Tumor Cells (CTCs): An Overview of Current Techniques and Its Potential Clinical Implications","authors":"H. Krishna, S. Dixit","doi":"10.21088/ijgmr.2319.4782.8219.3","DOIUrl":"https://doi.org/10.21088/ijgmr.2319.4782.8219.3","url":null,"abstract":"","PeriodicalId":113499,"journal":{"name":"Indian Journal of Genetics and Molecular Research","volume":"64 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132795311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.21088/ijgmr.2319.4782.8219.1
M. Sinha
{"title":"Assessment of Male Reproductive Health: Obesity, Sperm DNA Fragmentation, Yq micodeletion, Endocrinal Profile","authors":"M. Sinha","doi":"10.21088/ijgmr.2319.4782.8219.1","DOIUrl":"https://doi.org/10.21088/ijgmr.2319.4782.8219.1","url":null,"abstract":"","PeriodicalId":113499,"journal":{"name":"Indian Journal of Genetics and Molecular Research","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122147814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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